Q5WWU9

PR
Gene name
tmk
Protein name
Thymidylate kinase
Names
dTMP kinase
Species
Legionella pneumophila (strain Lens)
KEGG Pathway
lpf:lpl1350
EC number
2.7.4.9: Phosphotransferases with a phosphate group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

118-189 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5WWU9

Entry ID Method Resolution Chain Position Source
AF-Q5WWU9-F1 Predicted AlphaFoldDB

No variants for Q5WWU9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5WWU9

No associated diseases with Q5WWU9

4 regional properties for Q5WWU9

Type Name Position InterPro Accession
domain Protein kinase domain 4 - 288 IPR000719
active_site Serine/threonine-protein kinase, active site 123 - 135 IPR008271
binding_site Protein kinase, ATP binding site 10 - 33 IPR017441
domain Cyclin-dependent kinase 20-like, catalytic domain 3 - 289 IPR048002

Functions

Description
EC Number 2.7.4.9 Phosphotransferases with a phosphate group as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
thymidylate kinase activity Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate.

3 GO annotations of biological process

Name Definition
dTDP biosynthetic process The chemical reactions and pathways resulting in the formation of dTDP, deoxyribosylthymine diphosphate (2'-deoxyribosylthymine5'-diphosphate).
dTTP biosynthetic process The chemical reactions and pathways resulting in the formation of dTTP, deoxyribosylthymine triphosphate.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSSLTGKLIV IEGLEGAGKS TAVNLVVELL SQKKISTITT REPGGTKIGE ILRSIIKNPE
70 80 90 100 110 120
YNNVLDDRSE LLLLYAARIQ LIEQVIKPAL NVGQWVIADR FELSTLAYQG GGRKMDMRVI
130 140 150 160 170 180
NELSNFCLKG FKPDLTLYLD INPELGMIRA KSRGKFDRIE QESIEFFHRI HDTYHILVKQ
190 200 210
NPEIMMIDAN RSLEEVQSSI QSVIEEFIEH NL