Q5WKF5

PR
Gene name
cysH
Protein name
Adenosine 5'-phosphosulfate reductase
Names
APS reductase, 5'-adenylylsulfate reductase, Thioredoxin-dependent 5'-adenylylsulfate reductase
Species
Alkalihalobacillus clausii (strain KSM-K16) (Bacillus clausii)
KEGG Pathway
bcl:ABC0611
EC number
1.8.4.10: With a disulfide as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

116-189 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5WKF5

Entry ID Method Resolution Chain Position Source
AF-Q5WKF5-F1 Predicted AlphaFoldDB

No variants for Q5WKF5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5WKF5

No associated diseases with Q5WKF5

1 regional properties for Q5WKF5

Type Name Position InterPro Accession
domain Phosphoadenosine phosphosulphate reductase 29 - 257 IPR002500

Functions

Description
EC Number 1.8.4.10 With a disulfide as acceptor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
adenylyl-sulfate reductase (thioredoxin) activity Catalysis of the reaction: AMP + sulfite + thioredoxin disulfide = 5'-adenylyl sulfate + thioredoxin.
metal ion binding Binding to a metal ion.
phosphoadenylyl-sulfate reductase (thioredoxin) activity Catalysis of the reaction: adenosine 3',5'-diphosphate + H(+) + sulfite + thioredoxin disulfide = 3'-phospho-5'-adenylyl sulfate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin; 3'-phosphoadenosine 5'-phosphosulfate is also known as PAPS.

2 GO annotations of biological process

Name Definition
cysteine biosynthetic process The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid.
sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) The pathway by which inorganic sulfate is processed and incorporated into sulfated compounds, where the phosphoadenylyl sulfate reduction step is catalyzed by the enzyme phosphoadenylyl-sulfate reductase (thioredoxin) (EC:1.8.4.8).

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAYVFEQMEA TDYEKVNTKL KNRDSLDILR WANQTYGEKL VYACSFGAEA MVLLDLLSKI
70 80 90 100 110 120
QKEAHILFLD TDFHFAETYE LIERVKERYP TFRINMAKPA LSPEEQAERY GDELWLKNPD
130 140 150 160 170 180
QCCQIRKLDV LARELEPYDA WLSGLRREQS PTRANTEFVN QDKRFKKVKV CPLIHWTEEE
190 200 210 220 230 240
IWMYIKLHQL PYNELHDQHY PSIGCTYCTK AVMPGEDARS GRWAGTGKTE CGLHAPTKGD
S