Q5W1J6

PR
Gene name
foxm1
Protein name
Forkhead box protein M1
Names
XlFoxM1
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:496385
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

330-410 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5W1J6

Entry ID Method Resolution Chain Position Source
AF-Q5W1J6-F1 Predicted AlphaFoldDB

No variants for Q5W1J6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5W1J6

No associated diseases with Q5W1J6

4 regional properties for Q5W1J6

Type Name Position InterPro Accession
domain Fork head domain 258 - 352 IPR001766
conserved_site Fork head domain conserved site1 260 - 273 IPR018122
conserved_site Fork head domain conserved site 2 305 - 311 IPR030456
domain Forkhead box protein M1, forkhead domain 260 - 336 IPR047516

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
DNA-binding transcription factor activity A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
sequence-specific DNA binding Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.

2 GO annotations of biological process

Name Definition
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
G2/M transition of mitotic cell cycle The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRTSPRRPLI LKRRKLSLPH QDATPCPGAS EQGKAAMMKT ANLPEQTLAH ELEDMAPKSK
70 80 90 100 110 120
ADQETPGQNE GGDTLGQSLA PTMRLPSNPP QSCPEDIPGF PSGVRIMGHP TMADAQLVII
130 140 150 160 170 180
PSQSNVQSII QALTARGKEQ GGPNKYIIIS SESAIQTQAW HQGPQIKEEE CVNSQSEATC
190 200 210 220 230 240
ISKQKPTGNS RKAKHRQEEQ LNASLSNIQW LGNMSSESLG QYSIKEEQED KENQIPECAK
250 260 270 280 290 300
MEEEPQSFPD PQWPLSVTER PPYSYMALIQ FAINSTPRKR MTLKDIYTWI EDHFPYFKHV
310 320 330 340 350 360
AKPGWKNSIR HNLSLHDMFV RESEANNKVS YWTIHPQANR CLTLDQVFKT ASPMSPADNE
370 380 390 400 410 420
PQKKMIPDIR KSFQSAACAS NKERKMKPLL PRVNSYLIPV HFPVAQPVLL PALEPYAFGA
430 440 450 460 470 480
ESSDGQQSSK RVKIAPKATA DDGESPKHLG LCSVKEEPDI SNLKCEDLFQ CKRVSSSRRK
490 500 510 520 530 540
QQLLPPHSEE PELVLPESIA SDSGLDTDFS FIQDASANPN QNLTSHPTQN CPSNVTQEGL
550 560 570 580 590 600
LHLTHDGPSY LTQVSSSHFT QDDPCQFTKD DTFYFTQDNP IQLTQDEDYT FKTPIKEHFS
610 620 630 640 650 660
KPTTSSTPSK PTDTGLLQPW ESETSLPRDP VLDFSPVRIP QGSTFTPFKD NLGTLSFGDT
670 680 690 700 710 720
PFKDFGIFGS PQNLLNALSP ASSPLLRLES PCVSRQQKRC SKELQVGASA NRSLLEGLVL
730 740 750
DTVDDSLSKI LLDISFSGME EGNGLEVDGV WSQFLPEFK