Q5VQ69

PR
Gene name
Os06g0144800 (LOC_Os06g05250, OsJ_20104, OSJNBa0007O20.17)
Protein name
Translation factor GUF1 homolog, mitochondrial
Names
Elongation factor 4 homolog, EF-4, GTPase GUF1 homolog, Ribosomal back-translocase
Species
Oryza sativa subsp japonica (Rice)
KEGG Pathway
osa:4340102
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-75 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5VQ69

Entry ID Method Resolution Chain Position Source
AF-Q5VQ69-F1 Predicted AlphaFoldDB

No variants for Q5VQ69

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5VQ69

No associated diseases with Q5VQ69

6 regional properties for Q5VQ69

Type Name Position InterPro Accession
domain Elongation factor EFG, domain V-like 465 - 550 IPR000640
domain Translational (tr)-type GTP-binding domain 55 - 247 IPR000795
domain Small GTP-binding protein domain 59 - 233 IPR005225
domain GTP-binding protein LepA, C-terminal 552 - 658 IPR013842
conserved_site Tr-type G domain, conserved site 95 - 110 IPR031157
domain Elongation factor 4, domain IV 465 - 544 IPR035654

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

4 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
mitochondrial ribosome binding Binding to a mitochondrial ribosome.
ribosome binding Binding to a ribosome.

2 GO annotations of biological process

Name Definition
positive regulation of translation Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
translation The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P46943 GUF1 Translation factor GUF1, mitochondrial Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
C5Z3W1 Sb10g003070 Translation factor GUF1 homolog, mitochondrial Sorghum bicolor (Sorghum) (Sorghum vulgare) PR
10 20 30 40 50 60
MAGAAALRRS ARRVVLPGAY ALSRALQHPE RLLSSQASPD RGGVLGSELG LYPPERVRNF
70 80 90 100 110 120
SIIAHVDHGK STLADRLLEL TGTIKKGHGQ PQYLDKLQVE RERGITVKAQ TATMFYRHAN
130 140 150 160 170 180
NQLPASDQPD APSYLLNLID TPGHVDFSYE VSRSLAACQG ALLVVDAAQG VQAQTIANFY
190 200 210 220 230 240
LAFESNLSII PVINKIDQPT ADPDNVKAQL KRLFDIDPSE ALLTSAKTGQ GLSQVLPAVI
250 260 270 280 290 300
ERIPSPPGKC DSPVRMLLLD SYYDEYKGVI CHVAVVDGAL HKGDKIASAA TGRTYEVLDV
310 320 330 340 350 360
GIMHPELTPT GVLYTGQVGY VISGMRSTKE ARIGDTLHQA KSIVEPLPGF KPARHMVFSG
370 380 390 400 410 420
LYPADGSDFD ALSHAIEKLT CNDASVSVTK ETSTALGMGF RCGFLGLLHM DVFHQRLEQE
430 440 450 460 470 480
HGAQVISTIP TVPYIFEYGD GSKVQVENPA ALASNPGKRI AACWEPTVIA TIIIPSEYVG
490 500 510 520 530 540
PVIMLCSERR GEQQEYTFID AQRALLKYRL PLREIIVDFY NELKSITSGY ATFDYEDSEY
550 560 570 580 590 600
QQSDLVKMDI LLNGQPVDAM ATIVHNQKAQ RVGRELVDKL KKFIERQMFE ITIQAAVGSK
610 620 630 640 650 660
VIARETLSAM RKNVLAKCYG GDITRKKKLL EKQKEGKKRM KRVGSVDIPQ EAFHELLKVS
NSK