Q5UQG7
Gene name |
MIMI_R818 |
Protein name |
Putative serine/threonine-protein kinase/receptor R818 |
Names |
|
Species |
Acanthamoeba polyphaga mimivirus (APMV) |
KEGG Pathway |
vg:9925481 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
932-940 (Activation loop from InterPro)
Target domain |
793-1057 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
954-958 (Activation loop from InterPro)
Target domain |
793-1057 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
1532-1553 (Activation loop from InterPro)
Target domain |
1394-1645 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
0 structures for Q5UQG7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|
No variants for Q5UQG7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5UQG7 | |||||
No associated diseases with Q5UQG7
11 regional properties for Q5UQG7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 793 - 1057 | IPR000719-1 |
| domain | Protein kinase domain | 1394 - 1645 | IPR000719-2 |
| domain | Adenylyl cyclase class-3/4/guanylyl cyclase | 1033 - 1313 | IPR001054 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 794 - 1053 | IPR001245-1 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 1394 - 1639 | IPR001245-2 |
| active_site | Serine/threonine-protein kinase, active site | 911 - 923 | IPR008271-1 |
| active_site | Serine/threonine-protein kinase, active site | 1511 - 1523 | IPR008271-2 |
| binding_site | Protein kinase, ATP binding site | 799 - 821 | IPR017441-1 |
| binding_site | Protein kinase, ATP binding site | 1400 - 1422 | IPR017441-2 |
| domain | PBP domain | 51 - 326 | IPR024370-1 |
| domain | PBP domain | 431 - 661 | IPR024370-2 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cyclic nucleotide biosynthetic process | The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKSIGIFVVA | LWLTHFCDGG | QLGARIYSSG | SESSVLLFDQ | YINKYAFTNG | DVKIIYEGKS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IFEILSETYV | TDFNIFDRAI | SQDNLDMFQI | VQFPLAGQAI | VMTYNLPELV | NSSYRLVIDR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ETLGKIWYGA | ISKWNDTAIQ | NLNPTVGHLL | PDTDIILGYS | DDYIMTISGL | IKMALSSFSP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EFDTELKYAN | NTFNGMNPTK | NGRGHNIGET | STVRLEWLKK | TSYGLTYINY | ADVYNNGTDS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TVPMNMYNKA | GYFVEPNLVS | VQAAMSDFKI | FYANNNSTID | IYDAPGNKSW | PLAYVNYLGC |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SSAFGPMADC | TRTIQMTNFI | AWIYTNDAAS | ESAIELQFYP | LDKTLQKVAI | DNLYNIKCNN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IAVLSQQYLI | GFGAPISVMS | LWPNSWTTVA | STARYYSAPS | SQALELQETY | GADFGITVTG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VPNTYFNKMP | DLGVMPLAAF | TIVPAYNIPA | INGTNGTLIL | DYEIITDIYL | GIINNWNDSR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| IRALNGIEIN | RKLPNVSITV | IYQAVSSDYN | FMFTDFMSKK | SPKFAKKIGS | TYFPILTLPN |
| 550 | 560 | 570 | 580 | 590 | 600 |
| NSMIITTDIY | DVGNQLISNS | NSFAFWPYFG | ITMLSRQPTV | QAASIRTEKG | NIISSNSTTL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| EKAINNFISK | GGSIEDAPYI | MGENDESWPL | SALMTMIYRQ | STIHYAAKAA | AVADFAYWTQ |
| 670 | 680 | 690 | 700 | 710 | 720 |
| SNPTAINIAT | IQGMYVASNN | PTLKSRNLNL | LKNFVVDGEP | ISSIANCIYQ | GTICSDMGTC |
| 730 | 740 | 750 | 760 | 770 | 780 |
| NNNSCLCNSY | RKGIYCENIV | SSSGESIGII | LAIVIPVSFV | ICCIIIVLVI | ALIVSIRLHQ |
| 790 | 800 | 810 | 820 | 830 | 840 |
| RVEDEWEVDF | HELDFMESLG | SGGSGEVFKA | MWKGTEVAVK | KLVNSNITKD | AERNFKQEIH |
| 850 | 860 | 870 | 880 | 890 | 900 |
| RMTSLRHPNV | VLFMAASTRP | PNMCIVMEFM | SLGSLYDLLG | NELVTEIPPV | LRIRIAYQAA |
| 910 | 920 | 930 | 940 | 950 | 960 |
| KGMHFLHSSD | IVHRDLKSLN | LLLDSKWNVK | VSDFGLTKIK | DNNKGKSSTK | EDSVCSIQWT |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| APEVLSEKQD | IDYILADVYS | FGIIMWELMT | RLRPYIGLSP | AAIAVAVIRD | NLRPEIQEED |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| INLMSSDYVE | LVNICWHKDT | MIRPSFLEIM | TKLSTLIGGS | GITTGTSTSS | SNQSSDYIGP |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| NIITRTKNIH | NNDETKNSFG | STTYGSNTIS | SSSNTESDKI | LSKLNKKKIP | TGEVIIVFTD |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| IISAEQLWHH | NPLAMKNATV | LYNAVIRETL | DKIGGYESFI | YKDHNSGEGS | FCLVFQEAID |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| AIDFCSISQK | KLLEIDWPEE | LLDHPAAASE | KDINGTMIFA | GPRVRMGLHA | GTVKIMQDPV |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| TRRYEYSGVT | VNIAAKITMM | THGGQVIMSE | QVTDKISNND | CSNIKSLGQI | EITDTNNYKV |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| NIFELRIEGL | IGRFFGGVAF | YNYDSVTEST | DLDDTYPDSL | NFSTNGILYG | GIKQENEYLS |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| SAGLCRWIIN | YDDIQIGKQI | GVGSYGIVNM | GKWKNINVAV | KKFVKQKIDE | KQMLEFRAEI |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| AFLSQLRHPH | IILMIGACLK | RPNICIVTEF | MGNGSLRNVI | KTTKPEWKLK | IKMLYQTALG |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| IGYLHNSDPI | IIHRDIKPSN | ILVDDSMNVK | IADFGFARIK | EENSVMTRCG | TPCWTAPEII |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| RGEKYTEKVD | VFSFGIVMWE | VLTCKEPFSG | CNFMKVSMDI | LEGARPQIPS | DCPIDFTKLM |
| 1630 | 1640 | 1650 | |||
| KQCWHAKPDK | RPSMEDVIMG | LNDMLGPEKS | L |