Q5UPT2

PR
Gene name
UNG (MIMI_L249)
Protein name
Probable uracil-DNA glycosylase
Names
UDG
Species
Acanthamoeba polyphaga mimivirus (APMV)
KEGG Pathway
vg:9924856
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

8-116 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for Q5UPT2

Entry ID Method Resolution Chain Position Source
5X55 X-ray 230 A A/B 1-370 PDB
6LYD X-ray 260 A A 95-370 PDB
6LYE X-ray 310 A A 95-370 PDB

No variants for Q5UPT2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5UPT2

No associated diseases with Q5UPT2

2 regional properties for Q5UPT2

Type Name Position InterPro Accession
domain Uracil-DNA glycosylase-like 179 - 325 IPR005122
active_site Uracil-DNA glycosylase, active site 184 - 193 IPR018085

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

1 GO annotations of molecular function

Name Definition
uracil DNA N-glycosylase activity Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine.

1 GO annotations of biological process

Name Definition
base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSKKNVDPFS DSDSSSEPPS IFSSDNEENS DVDNSVIIND KNTKSDEADI KYMDEDESSD
70 80 90 100 110 120
SESESESKKK SKKSKKSKKS KKSVTKKKNN LLVGNRIITE YILIDANNYH FKSWIECFPD
130 140 150 160 170 180
CKVNLKLLLF RPEWFDFFKY VESKTYFPQL ESKLSSYLEK RQRIVPYPEL LFNTMNVLPP
190 200 210 220 230 240
GKIKVVILGQ DPYPGSCISG VPYAMGCSFS VPLNCPVPKS LANIYTNLIK FNHMRKAPKH
250 260 270 280 290 300
GCLASWILQG TFMINSAFTT VLNESGVHAR TWESFTADLI DYLTDNYDDL IFVAWGAHAH
310 320 330 340 350 360
KLCQRVDPKK HYIITSSHPS PYSVSNTMTS MSYGPNPKKV TYPSFNSVDH FGKINEHLKS
RNKKPIFWDL