Q5U526

PR
Gene name
eif4a3-a (ddx48-a)
Protein name
Eukaryotic initiation factor 4A-III-A
Names
eIF-4A-III-A, eIF4A-III-A, ATP-dependent RNA helicase DDX48-A, ATP-dependent RNA helicase eIF4A-3-A, DEAD box protein 48-A, Eukaryotic translation initiation factor 4A isoform 3 A
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-66 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5U526

Entry ID Method Resolution Chain Position Source
AF-Q5U526-F1 Predicted AlphaFoldDB

No variants for Q5U526

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5U526

No associated diseases with Q5U526

5 regional properties for Q5U526

Type Name Position InterPro Accession
conserved_site ATP-dependent RNA helicase DEAD-box, conserved site 189 - 197 IPR000629
domain Helicase, C-terminal 254 - 415 IPR001650
domain DEAD/DEAH box helicase domain 67 - 229 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 61 - 258 IPR014001
domain RNA helicase, DEAD-box type, Q motif 42 - 70 IPR014014

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Nucleus
  • Nucleus speckle
  • Cytoplasm
  • Nucleocytoplasmic shuttling protein
  • Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nuclear speck A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
spliceosomal complex Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

6 GO annotations of biological process

Name Definition
mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
mRNA transport The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.
regulation of alternative mRNA splicing, via spliceosome Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
regulation of translation Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
RNA splicing The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAAAAVAGVA GLTSGAGRKR LLREEDMTKV EFETSEEVDV TPTFDTMGLR EDLLRGIYAY
70 80 90 100 110 120
GFEKPSAIQQ RAIKQIIKGR DVIAQSQSGT GKTATFCVSV LQCLDIQVRE TQALILAPTR
130 140 150 160 170 180
ELAGQIQKVL LALGDYMNVQ CHACIGGTNV GEDIRKLDYG QHVVAGTPGR VFDMIRRRSL
190 200 210 220 230 240
RTRAIKMLVL DEADEMLNKG FKEQIYDVYR YLPPATQVCL ISATLPHEIL EMTNKFMTDP
250 260 270 280 290 300
IRILVKRDEL TLEGIKQFFV AVEREEWKFD TLCDLYDTLT ITQAVIFCNT KRKVDWLTEK
310 320 330 340 350 360
MREANFTVSS MHGDMPQKER ESIMKEFRSG ASRVLISTDV WARGLDVPQV SLIINYDLPN
370 380 390 400 410
NRELYIHRIG RSGRYGGKGV AINFVKNDDI RILRDIEQYY STQIDEMPMN VADLI