Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5TJE7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5TJE7-F1 | Predicted | AlphaFoldDB |
2 variants for Q5TJE7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs852379507 | 173 | R>C | No | EVA | |
| rs22221572 | 591 | Q>R | No | EVA |
No associated diseases with Q5TJE7
4 regional properties for Q5TJE7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | WD40 repeat | 227 - 264 | IPR001680-1 |
| repeat | WD40 repeat | 269 - 304 | IPR001680-2 |
| repeat | WD40 repeat | 349 - 390 | IPR001680-3 |
| domain | BING4, C-terminal domain | 441 - 519 | IPR012952 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| small-subunit processome | A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| METASKPGRD | VQPKKARLQT | KKKKPRRYWE | KEATLTAAGA | SPGPPRNKKR | NRELRPQRPK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NINLPKKSRI | PGKPQFPKKP | REQRNLEPQR | NLSGAQDPFP | GPAPIPEEVA | RKFRRIDKSK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KLPHSKSKTR | SRLEVAEAEE | EEISIKAARS | ELLLAEEPGF | LEGEDGEDTA | KIRQAEIVEA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VDIASAAKHF | DLNLRQFGPY | RLNYSPVGRH | LAFGGHRGHV | ATLDWVTKRL | MCEINVMEAV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RDIRFLHSEA | LFAVAQNRWL | HIYDNQGIEL | HCIRRCDRVT | RLEFLPFHFL | LATASETGFL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TYLDVSVGKI | VAALNARAGR | LDVMTKNPYN | AVIHLGHSNG | TVSLWSPAMK | EPLAKILCHR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GGVRAVAVDS | TGTYMATSGL | DHQLKIFDLR | GMFQPLSART | LPQGAGHLAF | SQRGLLAAGM |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SDVVNIWMGQ | GMASPPSLEQ | PYLTHRLSGH | VHGLHFCPFE | DVLGLGHSGG | ITSMLVPGAA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EPNFDGLENN | PYRSQKQRQE | WEVKALLEKV | PAELICLDPR | ALAEVDVISL | EQEKKERIER |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LGYDPEAKAP | FQPKPKQKGR | SSTASLVKRR | RKVMDKEHRD | KVRQSLEQQP | QKQEKKAKPL |
| 610 | |||||
| KARPSALDRF | VR |