AiPD: Autoinhibited Protein Database

Q5TEZ5

Gene name	C6orf163
Protein name	Uncharacterized protein C6orf163
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:206412
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

281-329 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

281-329 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q5TEZ5

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q5TEZ5-F1	Predicted				AlphaFoldDB

234 variants for Q5TEZ5

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA142870381 rs192134016	2	I>M		No	ClinGen 1000Genomes TOPMed gnomAD
CA364909159 rs935048089	6	D>H		No	ClinGen TOPMed gnomAD
rs935048089 CA142870383	6	D>N		No	ClinGen TOPMed gnomAD
CA364909160 rs935048089	6	D>Y		No	ClinGen TOPMed gnomAD
CA142870386 rs183868512	8	K>R		No	ClinGen 1000Genomes TOPMed gnomAD
CA364909216 rs1180136060	9	N>K		No	ClinGen gnomAD
rs1270187083 CA364909252	12	C>F		No	ClinGen gnomAD
rs1480376037 CA364909266	13	C>F		No	ClinGen gnomAD
rs1480376037 CA364909264	13	C>Y		No	ClinGen gnomAD
CA364909294 rs1174963487	16	C>G		No	ClinGen gnomAD
TCGA novel	17	N>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA142870397 rs939303377	18	K>E		No	ClinGen TOPMed gnomAD
CA364909348 rs1467024056	19	I>M		No	ClinGen TOPMed
CA364909345 rs1173038763	19	I>R		No	ClinGen TOPMed
CA364909339 rs1404185858	19	I>V		No	ClinGen TOPMed
rs1420016259 CA364909364	21	P>S		No	ClinGen TOPMed
CA3915194 rs143475317	22	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1303868729 CA364909383	23	A>T		No	ClinGen TOPMed gnomAD
rs934122897 CA142870437	24	P>A		No	ClinGen TOPMed gnomAD
rs1169934721 CA364909393	24	P>R		No	ClinGen gnomAD
rs767117567 CA3915195	28	T>I		No	ClinGen ExAC TOPMed gnomAD
rs1582102137 CA364909435	28	T>P		No	ClinGen Ensembl
rs1466953781 CA364909461	30	K>E		No	ClinGen TOPMed gnomAD
rs1466953781 CA364909459	30	K>Q		No	ClinGen TOPMed gnomAD
rs890000167 CA142870466	31	R>Q		No	ClinGen TOPMed gnomAD
CA142870456 rs771735516	31	R>W		No	ClinGen TOPMed gnomAD
rs1227907073 CA364909493	33	H>Q		No	ClinGen gnomAD
rs1250369129 CA364909494	34	E>K		No	ClinGen gnomAD
CA3915196 rs753075999	35	Y>*		No	ClinGen ExAC gnomAD
rs756624105 CA3915197	37	P>S		No	ClinGen ExAC gnomAD
rs1291835461 CA364909531	38	L>F		No	ClinGen gnomAD
CA142870483 rs1005802081	39	K>E		No	ClinGen Ensembl
CA142870484 rs529190200	41	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen 1000Genomes NCI-TCGA
CA3915198 rs113906669	41	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA364909613 rs41273287	45	H>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3915199 rs41273287	45	H>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1429423978 CA364909628	46	K>E		No	ClinGen gnomAD
CA364909646 rs1285229794	47	D>G		No	ClinGen TOPMed
rs941394435 CA142870511	48	I>M		No	ClinGen TOPMed gnomAD
CA364909671 rs757661923	49	L>P		No	ClinGen ExAC TOPMed gnomAD
rs757661923 CA3915200	49	L>Q		No	ClinGen ExAC TOPMed gnomAD
CA364910597 rs1262963165	50	D>V		No	ClinGen gnomAD
CA364910611 rs1459638769	51	I>T		No	ClinGen TOPMed
rs1324993433 CA364910606	51	I>V		No	ClinGen TOPMed
rs1562228780 CA364910633	53	A>E		No	ClinGen Ensembl
CA364910627 rs1246560219	53	A>T		No	ClinGen gnomAD
rs1446894201 CA364910646	54	N>S		No	ClinGen gnomAD
CA364910714 rs1562228791	59	E>*		No	ClinGen Ensembl
CA364910720 rs1212246626	59	E>V		No	ClinGen TOPMed
CA364910728 rs1454232823	60	E>K		No	ClinGen gnomAD
CA364910746 rs1319869554	61	Q>E		No	ClinGen TOPMed gnomAD
CA3915208 rs16879089	65	D>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA364910831 rs1257845477	66	I>T		No	ClinGen TOPMed
CA364910825 rs1454378860	66	I>V		No	ClinGen TOPMed gnomAD
rs1582104430 CA364910899	71	I>M		No	ClinGen Ensembl
CA364910907 rs9353479	72	A>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3915209 rs9353479	72	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1317050032 CA364910915	73	K>E		No	ClinGen gnomAD
CA364910929 rs1562228825	74	A>S		No	ClinGen Ensembl
rs1562228825 CA364910930	74	A>T		No	ClinGen Ensembl
CA364910958 rs1301573043	76	A>V		No	ClinGen TOPMed
CA364910995 rs1367165405	79	W>*		No	ClinGen TOPMed
rs1238954744 CA364911001	79	W>*		No	ClinGen gnomAD
rs1437515942 CA364910993	79	W>R		No	ClinGen TOPMed
CA142873864 rs572429182	81	Q>E		No	ClinGen 1000Genomes
rs764556409 CA3915217	83	N>D		No	ClinGen ExAC
CA364911135 rs1402405689	84	E>K		No	ClinGen gnomAD
CA364911168 rs1166359970	85	R>C		No	ClinGen TOPMed
CA364911172 rs1271119495	85	R>H		No	ClinGen TOPMed gnomAD
CA364911239 rs1582105296	88	Q>L		No	ClinGen Ensembl
rs952506982 CA142875052	90	V>G		No	ClinGen TOPMed
CA364911308 rs1310876309	92	K>E		No	ClinGen gnomAD
CA364911329 rs1206880002	93	A>S		No	ClinGen gnomAD
CA364911344 rs1233667110	94	L>F		No	ClinGen gnomAD
CA364911349 rs1480315050	95	E>K		No	ClinGen gnomAD
rs79002777 CA142875053	97	A>E		No	ClinGen TOPMed gnomAD
TCGA novel	97	A>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1562229282 CA364911380	97	A>T		No	ClinGen Ensembl
rs79002777 CA142875080	97	A>V		No	ClinGen TOPMed gnomAD
rs1456313870 CA364911583	105	I>T		No	ClinGen TOPMed
TCGA novel rs1582105349 CA364911719	110	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Ensembl
CA364911732 rs1254636451	111	E>G		No	ClinGen TOPMed
rs1214321324 CA364911765	113	Q>H		No	ClinGen TOPMed
CA142875119 rs565892854	114	K>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs755157273 CA3915225	122	K>E		No	ClinGen ExAC TOPMed gnomAD
CA364913113 rs1334397350	124	K>R		No	ClinGen TOPMed
CA364913123 rs1246066303	125	T>A		No	ClinGen gnomAD
CA364913212 rs1188079978	128	Y>C		No	ClinGen gnomAD
CA364913195 rs1171081134	128	Y>H		No	ClinGen TOPMed
rs200580279 CA142879028	131	M>T		No	ClinGen TOPMed gnomAD
TCGA novel	132	D>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA364913332 CA142879035 rs749300402	133	D>E		No	ClinGen ExAC TOPMed gnomAD
CA364913310 rs1166387960	133	D>N		No	ClinGen gnomAD
CA3915229 rs373869435	134	E>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3915228 COSM1446315 rs373869435	134	E>K	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA364913378 rs1323413920	135	M>I		No	ClinGen gnomAD
rs1582108670 CA364913369	135	M>T		No	ClinGen Ensembl
CA364913389 rs1348673308	136	K>N		No	ClinGen gnomAD
rs1403051367 CA364913384	136	K>R		No	ClinGen Ensembl
rs899589749 CA142879065	138	E>K		No	ClinGen TOPMed gnomAD
rs1582108680 CA364913424	138	E>V		No	ClinGen Ensembl
CA364913453 rs1364987082	139	H>Q		No	ClinGen TOPMed gnomAD
rs1271106596 CA364913442	139	H>R		No	ClinGen gnomAD
rs548052169 CA142879073	144	Q>E		No	ClinGen 1000Genomes TOPMed gnomAD
CA142879077 rs569592362	145	R>C		No	ClinGen 1000Genomes TOPMed gnomAD
CA3915231 rs538272595	145	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA364913573 rs538272595	145	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA142879083 rs549899195	147	V>I		No	ClinGen 1000Genomes TOPMed
rs549899195 CA364913636	147	V>L		No	ClinGen 1000Genomes TOPMed
CA3915232 rs571760546	148	H>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA364913668 rs1370496550	149	R>G		No	ClinGen TOPMed
CA142879087 rs879158325	152	R>S		No	ClinGen Ensembl
CA364913769 rs1167263199	153	I>T		No	ClinGen TOPMed
rs538712229 CA142879090	154	M>V		No	ClinGen 1000Genomes TOPMed
rs760159153 CA3915233	162	V>F		No	ClinGen ExAC gnomAD
rs777119064 CA3915235 COSM1580164	163	E>K	central_nervous_system [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
COSM1082333 CA364914088 rs1438713654	166	E>G	endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
TCGA novel	166	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA364914105 rs1444666614	167	K>E		No	ClinGen gnomAD
CA3915236 rs762313741	169	R>G		No	ClinGen ExAC gnomAD
CA364914146 rs1202329303	169	R>M		No	ClinGen TOPMed
CA364914144 rs1202329303	169	R>T		No	ClinGen TOPMed
CA3915237 rs765464174	170	A>T		No	ClinGen ExAC gnomAD
CA364914216 rs1388358512	172	E>D		No	ClinGen gnomAD
rs1227201529 CA364914197	172	E>K		No	ClinGen TOPMed
rs1433367707 CA364914248	174	H>R		No	ClinGen gnomAD
rs759494801 CA3915238	175	I>V		No	ClinGen ExAC TOPMed gnomAD
CA364914284 rs1244387542	176	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs766600195 CA3915240	177	Q>P		No	ClinGen ExAC gnomAD
CA364914348 rs1422033292	179	A>E		No	ClinGen gnomAD
rs1353003703 CA364914377	181	Q>K		No	ClinGen gnomAD
rs767404600 CA142879182	182	A>S		No	ClinGen Ensembl
rs1225386577 CA364914412	183	Q>*		No	ClinGen gnomAD
CA364916561 rs1337541392	186	K>E		No	ClinGen gnomAD
CA364916587 rs1443042883	187	A>T		No	ClinGen gnomAD
rs114836542 COSM1446317 CA3915244	188	V>M	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs1264749533 CA364916663	192	V>L		No	ClinGen TOPMed gnomAD
CA142884291 rs895952008	195	G>D		No	ClinGen TOPMed gnomAD
rs924773933 CA142884292	196	V>I		No	ClinGen TOPMed
rs1472751997 CA364916776	198	V>D		No	ClinGen TOPMed
rs753793927 CA142884295	201	D>N		No	ClinGen TOPMed
rs753793927 CA364916820	201	D>Y		No	ClinGen TOPMed
CA142884303 rs1056890584	203	K>E		No	ClinGen TOPMed gnomAD
rs1056890584 CA364916852	203	K>Q		No	ClinGen TOPMed gnomAD
CA142884307 rs1014421186	205	S>I		No	ClinGen Ensembl
rs1182307699 CA364916915	207	A>P		No	ClinGen gnomAD
rs76230292 CA3915245	208	R>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA3915246 rs756871957	208	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1210419242 CA364916957	210	M>L		No	ClinGen TOPMed
CA142884320 rs888378509	213	K>N		No	ClinGen TOPMed gnomAD
rs1582113266 CA364917016	214	E>*		No	ClinGen Ensembl
rs1465855877 CA364917019	214	E>A		No	ClinGen TOPMed gnomAD
CA364917026 rs1398940336	215	H>Y		No	ClinGen gnomAD
TCGA novel	220	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1005874952 CA142884325	221	Y>C		No	ClinGen TOPMed
CA364917307 rs1285188273	222	G>D		No	ClinGen gnomAD
CA142884328 rs367776534	222	G>S		No	ClinGen 1000Genomes TOPMed gnomAD
rs1285188273 CA364917309	222	G>V		No	ClinGen gnomAD
CA3915247 rs61740536	223	I>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1232278135 CA364917325	225	Q>P		No	ClinGen gnomAD
rs758177933 CA3915248	226	R>S		No	ClinGen ExAC gnomAD
rs1176443570 CA364917342	227	Q>H		No	ClinGen gnomAD
CA364917352 rs1340998508	229	Q>E		No	ClinGen gnomAD
TCGA novel	230	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1273263212 CA364917378	232	V>E		No	ClinGen gnomAD
rs1239431276 CA364917377	232	V>L		No	ClinGen TOPMed gnomAD
rs993570392 CA142884343	233	Q>H		No	ClinGen TOPMed
rs1481824272 CA364917385	233	Q>R		No	ClinGen gnomAD
CA3915249 rs779668933	235	V>M		No	ClinGen ExAC gnomAD
CA142884346 rs1030386204	236	L>P		No	ClinGen TOPMed
CA142884350 rs745328972	239	A>G		No	ClinGen Ensembl
CA364917465 rs1392885455	242	T>A		No	ClinGen TOPMed
CA364917470 rs1268679700	242	T>I		No	ClinGen TOPMed gnomAD
rs1432920841 CA364917486	243	H>Q		No	ClinGen gnomAD
CA3915250 rs771760676	246	T>I		No	ClinGen ExAC TOPMed gnomAD
rs1375185914 CA364917534	248	G>S		No	ClinGen gnomAD
rs1475853700 CA364917559	250	M>V		No	ClinGen gnomAD
CA364917610 rs1168261505	253	K>I	Variant assessed as Somatic; 0.0001777 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs375745961 CA142884372	256	N>D		No	ClinGen ESP gnomAD
CA364917657 rs1479121161	257	T>S		No	ClinGen TOPMed
rs768091881 CA3915251	258	Q>L		No	ClinGen ExAC
CA142884379 rs776135848	259	G>R		No	ClinGen ExAC TOPMed gnomAD
CA3915252 rs776135848	259	G>W		No	ClinGen ExAC TOPMed gnomAD
rs1391402262 CA364917687	260	E>K		No	ClinGen TOPMed gnomAD
CA364917705 rs1298891304	261	L>R		No	ClinGen gnomAD
CA364917740 rs1210444010	264	I>M		No	ClinGen TOPMed
CA364917760 rs1329253313	266	K>R		No	ClinGen TOPMed
CA3915254 rs770366853	267	Q>L		No	ClinGen ExAC TOPMed gnomAD
CA364917797 rs1369243084	269	G>A		No	ClinGen TOPMed
CA364917795 rs1369243084	269	G>E		No	ClinGen TOPMed
rs1296419866 CA364917804	270	I>L		No	ClinGen gnomAD
rs1339367765 CA364917840	273	N>I		No	ClinGen gnomAD
rs911074226 CA142884413	274	W>*		No	ClinGen TOPMed
rs911074226 CA142884405	274	W>C		No	ClinGen TOPMed
rs1224096626 CA364917845	274	W>R		No	ClinGen TOPMed gnomAD
COSM3831183 rs941258286 CA142884416	276	D>Y	breast [Cosmic]	No	ClinGen cosmic curated Ensembl
rs1562233389 CA364917866	277	F>L		No	ClinGen Ensembl
rs918215443 CA142884425	280	E>D		No	ClinGen Ensembl
CA142884420 rs1038709317	280	E>K		No	ClinGen Ensembl
CA142884440 rs929634763	283	Q>E		No	ClinGen TOPMed gnomAD
rs1416429951 CA364917914	284	E>K		No	ClinGen TOPMed
CA364917936 rs1354089824	287	M>V		No	ClinGen TOPMed gnomAD
CA142884445 rs1056174252	291	K>N		No	ClinGen TOPMed
rs1453581412 CA364917966	291	K>Q		No	ClinGen TOPMed
CA364918001 rs1208632270	295	Y>F		No	ClinGen gnomAD
CA142884451 rs917006970	296	T>A		No	ClinGen TOPMed gnomAD
rs766914244 CA3915258	296	T>I		No	ClinGen ExAC gnomAD
CA364918004 rs917006970	296	T>P		No	ClinGen TOPMed gnomAD
rs1188094301 CA364918018	298	P>S		No	ClinGen gnomAD
rs1465292063 CA364918022	299	K>Q		No	ClinGen TOPMed
rs896231969 CA142884459	300	L>R		No	ClinGen TOPMed
rs1446470955 CA364918045	302	P>R		No	ClinGen gnomAD
CA3915259 rs774648848	303	G>A		No	ClinGen ExAC TOPMed gnomAD
CA3915260 rs774648848	303	G>E		No	ClinGen ExAC TOPMed gnomAD
rs1368019111 CA364918055 COSM3669637	304	H>R	liver [Cosmic]	No	ClinGen cosmic curated gnomAD
CA3915261 rs767654551	306	D>G		No	ClinGen ExAC gnomAD
rs1386778517 CA364918089	307	F>C		No	ClinGen gnomAD
rs1291779107 CA364918083	307	F>L		No	ClinGen gnomAD
rs1319407341 CA364918126	310	P>A		No	ClinGen gnomAD
rs752854622 CA3915262	312	R>G		No	ClinGen ExAC TOPMed
rs1233022288 CA364918173	313	K>E		No	ClinGen TOPMed
rs756190189 CA3915263	314	K>Q		No	ClinGen ExAC gnomAD
rs1346183088 CA364918213	316	P>S		No	ClinGen TOPMed
rs748569043 CA142884502	318	N>I		No	ClinGen TOPMed
TCGA novel	318	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA364918305 rs1243249852	320	V>I		No	ClinGen gnomAD
CA364918392 rs770114344	324	N>D		No	ClinGen gnomAD
rs74563361 CA142884516	324	N>I		No	ClinGen Ensembl
CA142884511 rs770114344	324	N>Y		No	ClinGen gnomAD
rs758208955 CA3915267	325	K>E		No	ClinGen ExAC TOPMed gnomAD
rs1462806270 CA364918416	325	K>R		No	ClinGen gnomAD
CA364918446 rs1582113562	327	T>A		No	ClinGen Ensembl
rs772270834 CA142884521	329	D>H		No	ClinGen Ensembl
rs1255552907 CA364918516	330	D>W		No	ClinGen gnomAD

No associated diseases with Q5TEZ5

No regional properties for Q5TEZ5

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q5TEZ5

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

No GO annotations of cellular component

Name	Definition
No GO annotations for cellular component

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

No GO annotations of biological process

Name	Definition
No GO annotations for biological process

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q3V037	Gm136	Uncharacterized protein C6orf163 homolog	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MIRNSDYKNF	VCCAVCNKII	PPAPFGKTFK	RIHEYKPLKT	RFYTHKDILD	IGANILKKEE
70	80	90	100	110	120
QFQEDILREH	IAKAEAEVWA	QANERQKQAV	EKALEEANDR	HKIEIQILKE	EHQKDLQEVT
130	140	150	160	170	180
AKTKTEMYQN	MDDEMKREHL	AAEQRMVHRI	QRIMMECHRE	KVEAVEKARA	EERHIAQEAI
190	200	210	220	230	240
QAQKSKAVEE	IVNTGVTVIK	DEKTSVARLM	REKEHEMSIL	YGIAQRQRQE	EVQEVLQEAE
250	260	270	280	290	300
KTHQATLGNM	MDKLANTQGE	LLSIAKQLGI	MTNWKDFLEE	ELQETRMAFQ	KYINYTFPKL
310	320
SPGHADFILP	ERKKTPSNLV	IKENKTTLD