AiPD: Autoinhibited Protein Database

Q5T2D3

Gene name	OTUD3 (KIAA0459)
Protein name	OTU domain-containing protein 3
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:23252
EC number	3.4.19.12: Omega peptidases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

306-377 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

306-377 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for Q5T2D3

Entry ID	Method	Resolution	Chain	Position	Source
4BOU	X-ray	155 A	A	52-209	PDB
AF-Q5T2D3-F1	Predicted				AlphaFoldDB

313 variants for Q5T2D3

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA338812770 rs1362089965	6	A>T		No	ClinGen gnomAD
rs1229056894 CA338812803	7	A>V		No	ClinGen TOPMed
rs1226643525 CA338812871	10	R>W		No	ClinGen TOPMed gnomAD
rs1414246478 CA338812883	11	P>T		No	ClinGen TOPMed gnomAD
CA338812932 rs1423055462	12	G>D		No	ClinGen gnomAD
CA338812922 rs1168765870	12	G>S		No	ClinGen gnomAD
rs868459140 CA18895374	13	S>N		No	ClinGen gnomAD
CA338812976 rs1447940303	14	G>C		No	ClinGen TOPMed gnomAD
CA338812981 rs1303853819	14	G>D		No	ClinGen TOPMed gnomAD
CA338812977 rs1447940303	14	G>S		No	ClinGen TOPMed gnomAD
CA338812985 rs1303853819	14	G>V		No	ClinGen TOPMed gnomAD
CA18895382 rs931132257	16	R>Q		No	ClinGen TOPMed gnomAD
CA18895376 rs919782580	16	R>W		No	ClinGen TOPMed gnomAD
CA338813067 rs1275872757	18	A>D		No	ClinGen gnomAD
CA18895383 rs1037887199	19	E>D		No	ClinGen TOPMed gnomAD
CA338813084 rs1316783281	19	E>K		No	ClinGen gnomAD
rs201163171 CA657402	22	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA338813204 rs1440691963	22	R>S		No	ClinGen gnomAD
CA338813255 rs1191814308	24	R>W		No	ClinGen TOPMed gnomAD
CA18895401 rs901939041	25	D>N		No	ClinGen TOPMed gnomAD
rs901939041 CA338813277	25	D>Y		No	ClinGen TOPMed gnomAD
CA338813336 rs1172996079	26	E>G		No	ClinGen gnomAD
CA18895415 rs1046725375	28	A>V		No	ClinGen TOPMed gnomAD
CA657405 rs773380225	30	R>L		No	ClinGen ExAC TOPMed gnomAD
rs763528887 CA657406	31	R>Q		No	ClinGen ExAC gnomAD
CA338813587 rs1295982214	36	E>D		No	ClinGen gnomAD
CA338813576 rs569453344	36	E>K		No	ClinGen 1000Genomes TOPMed
CA18895435 rs569453344	36	E>Q		No	ClinGen 1000Genomes TOPMed
CA657407 rs530190493	37	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs530190493 CA338813593	37	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA338813608 rs1271485706	38	R>P		No	ClinGen gnomAD
rs372907505 CA18895446	40	R>L		No	ClinGen Ensembl
TCGA novel	40	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA338813647 rs1218616848	41	P>S	Variant assessed as Somatic; 0.0001332 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA18895454 rs1011691217	42	E>G		No	ClinGen TOPMed gnomAD
CA657411 rs760142848	44	G>D		No	ClinGen ExAC TOPMed gnomAD
CA18895476 rs1002556955	46	G>V		No	ClinGen TOPMed
CA338813756 rs1462394691	48	G>C		No	ClinGen TOPMed gnomAD
rs1195569769 CA338813772	49	C>Y		No	ClinGen gnomAD
rs1225949888 CA338813816	52	E>*		No	ClinGen TOPMed
CA338813819 rs1253386239	52	E>V		No	ClinGen TOPMed
CA657413 rs753480211	58	N>D		No	ClinGen ExAC TOPMed gnomAD
CA338813898 rs1334476801	58	N>S		No	ClinGen TOPMed gnomAD
CA338813918 rs1397369308	59	Q>H		No	ClinGen gnomAD
rs1181902287 CA338813912	59	Q>R		No	ClinGen TOPMed
CA338813927 rs1433367698	60	L>R		No	ClinGen gnomAD
CA338813938 rs1426608625	61	Q>H		No	ClinGen TOPMed
CA338813974 rs1343527624	65	L>P		No	ClinGen TOPMed gnomAD
CA338813990 rs1419980146	66	K>N		No	ClinGen gnomAD
rs1557671204 CA338814043	71	P>L		No	ClinGen Ensembl
rs778776410 CA657415	72	G>A		No	ClinGen ExAC gnomAD
CA338814050 rs778776410	72	G>E		No	ClinGen ExAC gnomAD
CA657431 rs760240630	76	C>*		No	ClinGen ExAC gnomAD
rs763594833 CA657432	77	L>F		No	ClinGen ExAC gnomAD
rs1471337669 CA338815455	78	F>L		No	ClinGen gnomAD
rs776054462 CA657433	80	A>G		No	ClinGen ExAC gnomAD
CA338815469 rs1388056357	81	L>V		No	ClinGen gnomAD
CA338815526 rs1463662899	89	S>P		No	ClinGen gnomAD
CA657435 rs536348725	90	R>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA657437 rs758098056 COSM1719835	90	R>Q	Variant assessed as Somatic; 9.277e-05 impact. NS [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
TCGA novel	90	R>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA338815535 rs1247127060	91	N>D		No	ClinGen gnomAD
rs1428870221 CA338815556	94	K>E		No	ClinGen gnomAD
rs889427048 CA18902300 COSM1185355	94	K>R	lung [Cosmic]	No	ClinGen cosmic curated Ensembl
rs1371669730 CA338815567	95	H>R		No	ClinGen TOPMed
CA18902303 rs199573234	97	Q>E		No	ClinGen Ensembl
CA657439 rs751538309	97	Q>R		No	ClinGen ExAC gnomAD
rs554603015 CA657440	98	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA338815584 rs554603015	98	E>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA338815596 rs1282652331	99	T>I		No	ClinGen gnomAD
CA338815624 CA657441 rs190906083	103	M>I		No	ClinGen 1000Genomes ExAC gnomAD
CA338815622 rs1304562040	103	M>T		No	ClinGen TOPMed
CA18902319 rs1010593765	103	M>V		No	ClinGen Ensembl
CA657442 rs540260034	104	I>T		No	ClinGen 1000Genomes ExAC gnomAD
CA338815626 rs1361184228	104	I>V		No	ClinGen Ensembl
rs1275175684 CA338815649	107	R>Q		No	ClinGen gnomAD
rs765352475 CA18902323	107	R>W		No	ClinGen TOPMed
TCGA novel	116	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA338815721 rs1198602571	117	D>N		No	ClinGen gnomAD
CA657444 rs777824446	119	P>R		No	ClinGen ExAC gnomAD
rs1439931366 CA338815742	120	F>V		No	ClinGen gnomAD
CA338815770 rs771190012	123	H>Q		No	ClinGen ExAC TOPMed gnomAD
rs1472289671 CA338815772	124	V>M		No	ClinGen gnomAD
rs1315021274 CA338815797	126	S>G		No	ClinGen gnomAD
CA18904927 rs966283051	131	G>A		No	ClinGen TOPMed
rs1440893087 CA338815849	133	F>S		No	ClinGen TOPMed
CA338815897 rs1366428667	136	N>S		No	ClinGen TOPMed gnomAD
rs1309301545 CA338815906	137	D>Y		No	ClinGen gnomAD
CA338815925 rs1426161084	138	A>E		No	ClinGen TOPMed
rs1255872577 CA338815940	139	I>T		No	ClinGen gnomAD
rs778112027 CA657461	139	I>V		No	ClinGen ExAC gnomAD
rs1346169418 CA338815949	140	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1163836353 CA338815966	141	A>D		No	ClinGen TOPMed
CA657463 rs757436022	143	A>T		No	ClinGen ExAC gnomAD
rs1487139882 CA338815996	143	A>V		No	ClinGen gnomAD
rs375869805 CA18905019	144	R>T		No	ClinGen ESP TOPMed
rs1330352962 CA338816021	145	N>S		No	ClinGen TOPMed
CA338816070 rs1192457958	147	Q>H		No	ClinGen gnomAD
rs779266574 CA657464	148	L>F		No	ClinGen ExAC gnomAD
CA338816132 rs1429729097	152	I>S		No	ClinGen gnomAD
CA18905033 rs935697141	155	L>F		No	ClinGen Ensembl
rs565425521 CA18905047	156	N>D		No	ClinGen Ensembl
TCGA novel	156	N>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs746185753 CA657465	157	A>S		No	ClinGen ExAC gnomAD
CA657466 rs772599029	157	A>V		No	ClinGen ExAC gnomAD
rs1175353265 CA338816210	158	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs775945726 CA657467	161	Q>*		No	ClinGen ExAC gnomAD
CA338816818 rs371092366	162	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA18907746 rs917426897	162	I>V		No	ClinGen TOPMed gnomAD
CA657498 rs760544978	163	R>C		No	ClinGen ExAC TOPMed gnomAD
CA338816823 rs764047355	163	R>H		No	ClinGen ExAC TOPMed gnomAD
rs764047355 CA657499	163	R>P		No	ClinGen ExAC TOPMed gnomAD
CA18907772 rs528426495	165	T>A		No	ClinGen gnomAD
CA338816895 rs1265198806	168	S>N		No	ClinGen gnomAD
CA338816902 rs1463037708	169	S>G		No	ClinGen gnomAD
CA338816908 rs1557678411	169	S>T		No	ClinGen Ensembl
CA338816917 rs1400126100	170	V>M		No	ClinGen gnomAD
CA657501 rs544797762	171	R>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs976293809 CA18907807	172	E>*		No	ClinGen Ensembl
CA657503 rs375390419	174	H>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs1377403155 CA338816990	175	I>V		No	ClinGen TOPMed gnomAD
rs199964779 CA657506	178	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA657505 rs780294087	178	R>W		No	ClinGen ExAC gnomAD
CA657507 rs200380749	179	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs1234431674 CA338817026	180	G>R		No	ClinGen gnomAD
TCGA novel	182	H>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA338817052 rs1345407310	183	Y>C		No	ClinGen gnomAD
rs770547354 CA657510 COSM902304	184	D>N	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs370880245 CA657511	185	S>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs771796005 CA657513	187	R>Q		No	ClinGen ExAC gnomAD
CA657512 COSM378865 rs745517322	187	R>W	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA657514 rs775175554	188	R>K		No	ClinGen ExAC gnomAD
rs1390689297 CA338817087	189	I>V		No	ClinGen gnomAD
rs1357808290 CA338817094	190	N>D		No	ClinGen TOPMed gnomAD
rs1357808290 CA338817092	190	N>H		No	ClinGen TOPMed gnomAD
rs201938614 CA338817096	190	N>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs201938614 CA657515	190	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1291184609 CA338817114	192	N>K		No	ClinGen TOPMed
CA338817117 rs1285721870	193	S>A		No	ClinGen gnomAD
rs768516517 CA657516	193	S>L		No	ClinGen ExAC TOPMed gnomAD
rs776608771 CA657517	196	P>T		No	ClinGen ExAC TOPMed gnomAD
CA657519 rs765297375	200	Q>H		No	ClinGen ExAC gnomAD
CA338817163 rs1360618637	200	Q>R		No	ClinGen gnomAD
CA657520 rs773217184	201	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs773217184 CA18907933	201	T>R		No	ClinGen ExAC gnomAD
rs766583675 CA657522	202	D>N		No	ClinGen ExAC gnomAD
rs759880608 CA657542	205	M>V		No	ClinGen ExAC gnomAD
rs767927110 CA657543	209	D>E		No	ClinGen ExAC gnomAD
CA338817866 rs1319788751	210	E>G		No	ClinGen gnomAD
rs992476206 CA18911577	211	S>T		No	ClinGen gnomAD
rs753050918 CA657544	212	N>K		No	ClinGen ExAC gnomAD
CA338817906 rs1295417793	216	K>E		No	ClinGen TOPMed
CA657546 rs764658974	217	I>T		No	ClinGen ExAC
TCGA novel	218	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1237607770 CA338817935	220	K>E		No	ClinGen gnomAD
rs1420465997 CA338817939	220	K>N		No	ClinGen gnomAD
rs1288705222 CA338817941	221	G>R		No	ClinGen Ensembl
CA657547 rs749998612	222	M>V		No	ClinGen ExAC TOPMed
CA657548 rs757904396	223	D>N		No	ClinGen ExAC gnomAD
CA657549 rs779631390	224	S>F		No	ClinGen ExAC gnomAD
CA18911613 rs61750789	227	D>A		No	ClinGen Ensembl
CA338817988 rs1472017924	227	D>E		No	ClinGen TOPMed
CA657551 COSM182650 rs754522313	227	D>N	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	232	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs942067693 CA18911616	233	E>D		No	ClinGen Ensembl
rs941063477 CA18911631	235	A>T		No	ClinGen TOPMed gnomAD
CA657553 rs780985847	236	V>I		No	ClinGen ExAC TOPMed gnomAD
CA657554 rs546445307	238	K>E		No	ClinGen 1000Genomes ExAC gnomAD
CA657555 rs769762740	240	C>Y		No	ClinGen ExAC gnomAD
rs1425193576 CA338818079	241	N>D		No	ClinGen TOPMed
rs1364728150 CA338818090	242	A>V		No	ClinGen gnomAD
CA657556 rs142250482	243	T>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA18911673 rs142250482	243	T>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	244	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA338818126 rs1311291528	247	D>N		No	ClinGen gnomAD
rs1355140013 CA338818139	248	F>C		No	ClinGen TOPMed gnomAD
rs1355140013 CA338818138	248	F>S		No	ClinGen TOPMed gnomAD
rs1295255927 CA338818152	250	L>*		No	ClinGen gnomAD
CA338818151 rs1415617984	250	L>V		No	ClinGen gnomAD
CA338818160 rs1179798620	251	I>T		No	ClinGen gnomAD
rs772465704 CA657581	251	I>V		No	ClinGen ExAC TOPMed gnomAD
CA338818173 rs1227385846	253	Q>R		No	ClinGen gnomAD
CA657584 rs769138536	256	E>*		No	ClinGen ExAC gnomAD
TCGA novel	259	N>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA657585 rs186008071	260	Y>C		No	ClinGen 1000Genomes ExAC gnomAD
rs1557681615 CA338818220	260	Y>H		No	ClinGen Ensembl
rs762397335 CA657586	261	N>Y		No	ClinGen ExAC gnomAD
rs564836449 CA657587	262	I>T		No	ClinGen 1000Genomes ExAC gnomAD
CA18912003 rs1000574528	262	I>V		No	ClinGen Ensembl
rs751120284 CA657588	263	E>V		No	ClinGen ExAC gnomAD
rs1373505532 CA338818253	265	A>S		No	ClinGen gnomAD
rs767214580 CA657590	266	I>T		No	ClinGen ExAC gnomAD
CA657589 rs758946019	266	I>V		No	ClinGen ExAC gnomAD
rs1374603657 CA338818268	267	I>M		No	ClinGen gnomAD
CA18912038 rs61752515	268	A>P		No	ClinGen Ensembl
CA657591 rs752338966	268	A>V		No	ClinGen ExAC TOPMed gnomAD
CA657593 rs200790645	269	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA657594 rs532238566	270	L>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	270	L>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA657595 rs532238566	270	L>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs369009180 CA657598	271	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA657599 rs372656324	271	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA657597 rs369009180	271	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1571183279 CA338818284	272	M>L		No	ClinGen Ensembl
rs1395869858 CA338818298	273	N>S		No	ClinGen TOPMed
CA338818303 rs1211180738	274	Q>*		No	ClinGen gnomAD
rs1489042204 CA338818490	279	N>K		No	ClinGen TOPMed
CA338818501 rs1365626813	280	A>G		No	ClinGen gnomAD
CA338818503 rs1365626813	280	A>V		No	ClinGen gnomAD
CA18913050 rs1054525313	283	N>D		No	ClinGen Ensembl
TCGA novel	283	N>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
VAR_087061 rs78466831 CA657619	288	G>D	found in a family with an early age of onset of diabetes; unknown pathological significance; reduced the stability and catalytic activity [UniProt]	No	ClinGen 1000Genomes ExAC TOPMed gnomAD UniProt
CA657620 rs191701178	289	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA338818607 rs191701178	289	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA338818612 rs781247080	289	R>P		No	ClinGen ExAC gnomAD
rs781247080 CA657621	289	R>Q		No	ClinGen ExAC gnomAD
CA18913072 rs775608626	290	V>E		No	ClinGen TOPMed gnomAD
CA657622 rs200185091	290	V>M		No	ClinGen ExAC TOPMed gnomAD
CA338818676 rs773554496	294	C>W		No	ClinGen ExAC gnomAD
CA657625 rs564519845	296	P>R		No	ClinGen 1000Genomes ExAC gnomAD
CA338818755 rs1223630841	302	G>D		No	ClinGen gnomAD
rs377681109 CA338818764	303	S>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs377681109 CA657627	303	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs760149018 CA657628	304	G>D		No	ClinGen ExAC gnomAD
rs1207402468 CA338818793	305	A>S		No	ClinGen TOPMed gnomAD
CA657629 rs763859266	308	F>L		No	ClinGen ExAC gnomAD
rs776138793 CA657630	309	G>E		No	ClinGen ExAC gnomAD
CA657631 rs761739384	310	N>S		No	ClinGen ExAC gnomAD
CA338818975 rs1418642067	312	G>S		No	ClinGen TOPMed gnomAD
rs764945746 CA657632	314	N>I		No	ClinGen ExAC gnomAD
rs764945746 CA657633	314	N>S		No	ClinGen ExAC gnomAD
rs763007582 CA657634	315	E>*		No	ClinGen ExAC gnomAD
TCGA novel	315	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA338819125 rs1557682294	317	R>K		No	ClinGen Ensembl
rs1334271087 CA338819169	319	E>D		No	ClinGen TOPMed
CA657638 rs755094105	319	E>K		No	ClinGen ExAC TOPMed gnomAD
VAR_051258 CA657640 rs2298110	321	N>S		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA18913209 rs201480887	323	A>V		No	ClinGen Ensembl
rs562238027 CA18913224	326	S>T		No	ClinGen 1000Genomes gnomAD
CA18913246 rs879357470 COSM1260728	327	P>L	oesophagus [Cosmic]	No	ClinGen cosmic curated TOPMed
CA657642 rs370284415	327	P>S		No	ClinGen ESP ExAC gnomAD
rs778017549 CA657643	328	S>N		No	ClinGen ExAC gnomAD
rs373747321 CA18913260	329	E>G		No	ClinGen ESP TOPMed gnomAD
CA657645 rs771465521	332	K>R		No	ClinGen ExAC gnomAD
CA657646 rs10916668 VAR_051259	333	A>T		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA338820393 rs1557682370	335	K>E		No	ClinGen Ensembl
rs1185303854 CA338820455	338	L>F		No	ClinGen gnomAD
rs372327524 CA657648	339	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1422253999 CA338820490	339	A>V		No	ClinGen gnomAD
rs199687893 CA657669	341	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA338820632 rs1222260015	342	T>P		No	ClinGen gnomAD
CA338820658 rs1283704262	343	N>K		No	ClinGen gnomAD
CA338820663 rs1317541099	344	K>E		No	ClinGen gnomAD
CA18913935 rs984516768	344	K>R		No	ClinGen TOPMed gnomAD
rs928634921 CA18913939	346	R>K		No	ClinGen TOPMed gnomAD
rs762905488 CA338820687	347	R>*		No	ClinGen ExAC TOPMed gnomAD
CA657673 rs762905488	347	R>G		No	ClinGen ExAC TOPMed gnomAD
rs61752512 CA657674	347	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA338820710 rs1315202761	350	Q>R		No	ClinGen TOPMed
rs1406640367 CA338820730	352	M>I		No	ClinGen TOPMed gnomAD
rs1571186940 CA338820725	352	M>V		No	ClinGen Ensembl
CA338820742 rs1161293648	354	K>E		No	ClinGen gnomAD
CA338820750 rs1272104318	355	K>E		No	ClinGen TOPMed
rs759414328 CA657677	356	K>Q		No	ClinGen ExAC TOPMed gnomAD
CA657679 rs775470797	357	R>Q		No	ClinGen ExAC gnomAD
CA657678 rs369363412	357	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	359	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs76871606 CA657681	359	E>G		No	ClinGen ExAC gnomAD
rs760784127 CA657680	359	E>K		No	ClinGen ExAC gnomAD
CA338820836 rs1279124834	360	E>G		No	ClinGen gnomAD
CA18913973 rs74812179	361	R>S		No	ClinGen Ensembl
rs1374151992 CA338820868 CA338820869	362	H>Q		No	ClinGen gnomAD
CA338820875 COSM182651 rs1230382652	363	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA657682 rs754057060	363	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA338820885 rs1482202797	364	H>N		No	ClinGen TOPMed
rs1183588597 CA338820928	366	A>G		No	ClinGen TOPMed
TCGA novel	366	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA338820940 rs1292503452	367	L>P		No	ClinGen gnomAD
CA338820936 rs1214826186	367	L>V		No	ClinGen TOPMed gnomAD
CA338820955 rs1436386099	368	E>G		No	ClinGen gnomAD
CA657684 rs765599979	369	S>N		No	ClinGen ExAC
CA657685 rs750741388 COSM4143231	370	R>S	thyroid [Cosmic]	No	ClinGen cosmic curated ExAC
rs758864460 CA338821003	371	G>D		No	ClinGen ExAC TOPMed gnomAD
CA657686 rs758864460	371	G>V		No	ClinGen ExAC TOPMed gnomAD
CA338821036 rs1388498979	373	H>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA657687 rs780582583	374	R>T		No	ClinGen ExAC TOPMed gnomAD
CA338821111 rs1183786718	377	N>S		No	ClinGen gnomAD
CA657689 rs200725243	378	R>G		No	ClinGen 1000Genomes ExAC
CA657690 rs777349228	378	R>K		No	ClinGen ExAC gnomAD
rs201731406 CA657691	379	S>G		No	ClinGen ExAC TOPMed gnomAD
CA18914035 rs749721253	379	S>N		No	ClinGen Ensembl
rs770657770 CA18914041	379	S>R		No	ClinGen ExAC TOPMed gnomAD
CA18914054 rs1039993167	380	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs901521084 CA18914073	381	A>T		No	ClinGen Ensembl
rs745643567 CA657694	383	A>G		No	ClinGen ExAC gnomAD
CA657693 rs774317957	383	A>T		No	ClinGen ExAC gnomAD
rs745643567 CA657695	383	A>V		No	ClinGen ExAC gnomAD
rs760734059 CA657697	384	N>D		No	ClinGen ExAC TOPMed gnomAD
CA657699 rs764163900	384	N>K		No	ClinGen ExAC gnomAD
rs373018769 CA657700	385	T>M		No	ClinGen ESP ExAC gnomAD
CA657702 rs375063759	386	Q>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA657703 rs768806192	387	V>I		No	ClinGen ExAC gnomAD
CA18914134 rs533389856	388	T>I		No	ClinGen 1000Genomes gnomAD
rs1228705673 CA338821307	390	V>L		No	ClinGen TOPMed
CA657705 rs199722871	394	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA657706 rs755482174	394	A>V		No	ClinGen ExAC gnomAD
rs142918335 CA657708	395	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs142918335 CA18914172	395	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA338821375 rs1383373551	396	L>V		No	ClinGen Ensembl
CA657709 rs757008985	398	I>F		No	ClinGen ExAC gnomAD
rs757008985 CA657710	398	I>L		No	ClinGen ExAC gnomAD
CA338821419 rs757008985	398	I>V		No	ClinGen ExAC gnomAD
TCGA novel	399	I>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA

No associated diseases with Q5T2D3

No regional properties for Q5T2D3

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q5T2D3

Functions

		Description
EC Number	3.4.19.12	Omega peptidases
Subcellular Localization	Cytoplasm Nucleus	Glucose or fatty acid promote nuclear translocation upon acetylation
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

1 GO annotations of molecular function

Name	Definition
cysteine-type deubiquitinase activity	An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated.

7 GO annotations of biological process

Name	Definition
negative regulation of protein kinase B signaling	Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
protein deubiquitination	The removal of one or more ubiquitin groups from a protein.
protein K11-linked deubiquitination	A protein deubiquitination process in which a K11-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 11 of the ubiquitin monomers, is removed from a protein.
protein K27-linked deubiquitination	A protein deubiquitination process in which a K27-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 27 of the ubiquitin monomers, is removed from a protein.
protein K48-linked deubiquitination	A protein deubiquitination process in which a K48-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is removed from a protein.
protein K6-linked deubiquitination	A protein deubiquitination process in which a K6-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 6 of the ubiquitin monomers, is removed from a protein.
protein stabilization	Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q96G74	OTUD5	OTU domain-containing protein 5	Homo sapiens (Human)	PR

10	20	30	40	50	60
MSRKQAAKSR	PGSGSRKAEA	ERKRDERAAR	RALAKERRNR	PESGGGGGCE	EEFVSFANQL
70	80	90	100	110	120
QALGLKLREV	PGDGNCLFRA	LGDQLEGHSR	NHLKHRQETV	DYMIKQREDF	EPFVEDDIPF
130	140	150	160	170	180
EKHVASLAKP	GTFAGNDAIV	AFARNHQLNV	VIHQLNAPLW	QIRGTEKSSV	RELHIAYRYG
190	200	210	220	230	240
EHYDSVRRIN	DNSEAPAHLQ	TDFQMLHQDE	SNKREKIKTK	GMDSEDDLRD	EVEDAVQKVC
250	260	270	280	290	300
NATGCSDFNL	IVQNLEAENY	NIESAIIAVL	RMNQGKRNNA	EENLEPSGRV	LKQCGPLWEE
310	320	330	340	350	360
GGSGARIFGN	QGLNEGRTEN	NKAQASPSEE	NKANKNQLAK	VTNKQRREQQ	WMEKKKRQEE
370	380	390
RHRHKALESR	GSHRDNNRSE	AEANTQVTLV	KTFAALNI