Q5SXH7

PR
Gene name
PLEKHS1
Protein name
Pleckstrin homology domain-containing family S member 1
Names
PH domain-containing family S member 1, Epididymis luminal protein 185, hEL185
Species
Homo sapiens (Human)
KEGG Pathway
hsa:79949
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

112-194 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5SXH7

Entry ID Method Resolution Chain Position Source
AF-Q5SXH7-F1 Predicted AlphaFoldDB

2 variants for Q5SXH7

Variant ID(s) Position Change Description Diseaes Association Provenance
VAR_080192 254 S>Y No UniProt
rs34024791
CA5696894
VAR_039275
 323 V>I No ClinGen
UniProt
1000Genomes
ESP
ExAC
TOPMed
dbSNP
gnomAD

No associated diseases with Q5SXH7

1 regional properties for Q5SXH7

Type Name Position InterPro Accession
domain Pleckstrin homology domain 14 - 131 IPR001849

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAGGKQFTFS YENEVCKQDY FIKSPPSQLF SSVTSWKKRF FILSKAGEKS FSLSYYKDHH
70 80 90 100 110 120
HRGSIEIDQN SSVEVGISSQ EKMQSVQKMF KCHPDEVMSI RTTNREYFLI GHDREKIKDW
130 140 150 160 170 180
VSFMSSFRQD IKATQQNTEE ELSLGNKRTL FYSSPLLGPS STSEAVGSSS PRNGLQDKHL
190 200 210 220 230 240
MEQSSPGFRQ THLQDLSEAT QDVKEENHYL TPRSVLLELD NIIASSDSGE SIETDGPDQV
250 260 270 280 290 300
SGRIECHYEP MESSFFKETS HESVDSSKEE PQTLPETQDG DLHLQEQGSG IDWCLSPADV
310 320 330 340 350 360
EAQTTNDQKG NIPDESQVEK LNVFLSPPDV INYLALTEAT GRICVSQWEG PPRLGCIFCH
370 380 390 400 410 420
GDHLLAVNDL KPQSLEEVSL FLTRSIQKED SFRILSYQVA FGEGTELRDR APGFRTSDRH
430 440 450 460
DVAKRACMES DWCRDSKTAP STNLCLSFLF CKIMTNDGAG CWIIK