Q5SQX6
PR
Gene name |
Cyfip2 |
Protein name |
Cytoplasmic FMR1-interacting protein 2 |
Names |
p53-inducible protein 121 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:76884 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5SQX6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5SQX6-F1 | Predicted | AlphaFoldDB |
62 variants for Q5SQX6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389154829 | 9 | D>H | No | EVA | |
| rs3389147122 | 13 | N>I | No | EVA | |
| rs3389115356 | 24 | D>E | No | EVA | |
| rs3400948454 | 46 | F>L | No | EVA | |
| rs3400948406 | 70 | N>H | No | EVA | |
| rs3389163322 | 111 | T>M | No | EVA | |
| rs3389154811 | 139 | E>V | No | EVA | |
| rs3389126958 | 140 | V>E | No | EVA | |
| rs3389147120 | 181 | V>I | No | EVA | |
| rs3389147060 | 185 | H>L | No | EVA | |
| rs3412942587 | 194 | F>Y | No | EVA | |
| rs3389152365 | 199 | A>T | No | EVA | |
| rs3389161850 | 214 | L>R | No | EVA | |
| rs3389152189 | 229 | E>* | No | EVA | |
| rs3389157055 | 308 | F>L | No | EVA | |
| 320 | K>E | RNA edited version [UniProt] | No | ||
| rs3389089973 | 384 | E>* | No | EVA | |
| rs3389150597 | 402 | K>E | No | EVA | |
| rs3389163312 | 406 | H>Q | No | EVA | |
| rs3413007375 | 417 | H>D | No | EVA | |
| rs3402230359 | 421 | K>N | No | EVA | |
| rs3402169394 | 427 | C>F | No | EVA | |
| rs3402147862 | 460 | L>* | No | EVA | |
| rs3389145053 | 462 | V>M | No | EVA | |
| rs3389150356 | 467 | M>I | No | EVA | |
| rs3389138877 | 480 | Y>* | No | EVA | |
| rs3389147135 | 488 | Q>* | No | EVA | |
| rs3389152196 | 523 | G>C | No | EVA | |
| rs3389150603 | 527 | P>L | No | EVA | |
| rs3389147063 | 550 | A>T | No | EVA | |
| rs3389157137 | 562 | R>H | No | EVA | |
| rs3389115347 | 600 | F>L | No | EVA | |
| rs3402147891 | 633 | R>* | No | EVA | |
| rs3402165759 | 639 | I>M | No | EVA | |
| rs3402071417 | 640 | E>D | No | EVA | |
| rs3402071389 | 641 | M>I | No | EVA | |
| rs3389145104 | 654 | T>A | No | EVA | |
| rs3389115313 | 671 | N>H | No | EVA | |
| rs3389138871 | 701 | F>S | No | EVA | |
| rs3389161771 | 736 | I>F | No | EVA | |
| rs3389154847 | 749 | L>M | No | EVA | |
| rs3401551666 | 750 | K>Q | No | EVA | |
| rs3389152184 | 786 | F>L | No | EVA | |
| rs3389150377 | 808 | H>D | No | EVA | |
| rs3389138901 | 867 | A>T | No | EVA | |
| rs3389089914 | 871 | T>I | No | EVA | |
| rs3389122644 | 927 | V>M | No | EVA | |
| rs240617401 | 968 | S>F | No | EVA | |
| rs3389150380 | 1012 | A>S | No | EVA | |
| rs3389152655 | 1016 | E>G | No | EVA | |
| rs3402168286 | 1016 | E>T | No | EVA | |
| rs3389122671 | 1039 | G>W | No | EVA | |
| rs3389150155 | 1040 | E>K | No | EVA | |
| rs3389147064 | 1060 | P>S | No | EVA | |
| rs3389138890 | 1066 | G>E | No | EVA | |
| rs3389145074 | 1067 | T>M | No | EVA | |
| rs3401953216 | 1111 | P>S | No | EVA | |
| rs3389163389 | 1153 | G>C | No | EVA | |
| rs3389148498 | 1178 | F>L | No | EVA | |
| rs3389150192 | 1179 | C>F | No | EVA | |
| rs3412117932 | 1180 | Y>F | No | EVA | |
| rs3389152744 | 1233 | S>F | No | EVA |
No associated diseases with Q5SQX6
Functions
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| neuron projection | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| perinuclear region of cytoplasm | Cytoplasm situated near, or occurring around, the nucleus. |
| SCAR complex | A pentameric complex that includes orthologues of human PIR121, Nap1, Abi, SCAR, and HSPC300 and regulates actin polymerization and/or depolymerization through small GTPase mediated signal transduction. |
| synapse | The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| small GTPase binding | Binding to a small monomeric GTPase. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| activation of cysteine-type endopeptidase activity | Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase. |
| apoptotic process | A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. |
| cell morphogenesis | The developmental process in which the size or shape of a cell is generated and organized. |
| cell-cell adhesion | The attachment of one cell to another cell via adhesion molecules. |
| dendrite extension | Long distance growth of a single dendrite involved in cellular development. |
| neuron projection development | The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). |
| positive regulation of neurotrophin TRK receptor signaling pathway | Any process that activates or increases the frequency, rate or extent of the neurotrophin TRK receptor signaling pathway. |
| positive regulation of proteolysis | Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein. |
| regulation of actin filament polymerization | Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q96F07 | CYFIP2 | Cytoplasmic FMR1-interacting protein 2 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTTHVTLEDA | LSNVDLLEEL | PLPDQQPCIE | PPPSSIMYQA | NFDTNFEDRN | AFVTGIARYI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EQATVHSSMN | EMLEEGHDYA | VMLYTWRSCS | RAIPQVKCNE | QPNRVEIYEK | TVEVLEPEVT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KLMKFMYFQR | KAIERFCSEV | KRLCHAERRK | DFVSEAYLLT | LGKFINMFAV | LDELKNMKCS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VKNDHSAYKR | AAQFLRKMAD | PQSIQESQNL | SMFLANHNRI | TQCLHQQLEV | IPGYEELLAD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IVNICVDYYE | NKMYLTPSEK | HMLLKVMGFG | LYLMDGNVSN | IYKLDAKKRI | NLSKIDKFFK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QLQVVPLFGD | MQIELARYIK | TSAHYEENKS | KWTCTQSSIS | PQYNICEQMV | QIRDDHIRFI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SELARYSNSE | VVTGSGLDSQ | KSDEEYRELF | DLALRGLQLL | SKWSAHVMEV | YSWKLVHPTD |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KFCNKDCPGT | AEEYERATRY | NYTSEEKFAF | VEVIAMIKGL | QVLMGRMESV | FNQAIRNTIY |
| 490 | 500 | 510 | 520 | 530 | 540 |
| AALQDFAQVT | LREPLRQAVR | KKKNVLISVL | QAIRKTICDW | EGGREPPNDP | CLRGEKDPKG |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GFDIKVPRRA | VGPSSTQLYM | VRTMLESLIA | DKSGSKKTLR | SSLDGPIVLA | IEDFHKQSFF |
| 610 | 620 | 630 | 640 | 650 | 660 |
| FTHLLNISEA | LQQCCDLSQL | WFREFFLELT | MGRRIQFPIE | MSMPWILTDH | ILETKEPSMM |
| 670 | 680 | 690 | 700 | 710 | 720 |
| EYVLYPLDLY | NDSAYYALTK | FKKQFLYDEI | EAEVNLCFDQ | FVYKLADQIF | AYYKAMAGSV |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LLDKRFRAEC | KNYGVIIPYP | PSNRYETLLK | QRHVQLLGRS | IDLNRLITQR | ISAAMYKSLD |
| 790 | 800 | 810 | 820 | 830 | 840 |
| QAISRFESED | LTSIVELEWL | LEINRLTHRL | LCKHMTLDSF | DAMFREANHN | VSAPYGRITL |
| 850 | 860 | 870 | 880 | 890 | 900 |
| HVFWELNFDF | LPNYCYNGST | NRFVRTAIPF | TQEPQRDKPA | NVQPYYLYGS | KPLNIAYSHI |
| 910 | 920 | 930 | 940 | 950 | 960 |
| YSSYRNFVGP | PHFKTICRLL | GYQGIAVVME | ELLKIVKSLL | QGTILQYVKT | LIEVMPKICR |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| LPRHEYGSPG | ILEFFHHQLK | DIIEYAELKT | DVFQSLREVG | NAILFCLLIE | QALSQEEVCD |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| LLHAAPFQNI | LPRVYIKEGE | RLEVRMKRLE | AKYAPLHLVP | LIERLGTPQQ | IAIAREGDLL |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| TKERLCCGLS | MFEVILTRIR | SYLQDPIWRG | PPPTNGVMHV | DECVEFHRLW | SAMQFVYCIP |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| VGTNEFTAEQ | CFGDGLNWAG | CSIIVLLGQQ | RRFDLFDFCY | HLLKVQRQDG | KDEIIKNVPL |
| 1210 | 1220 | 1230 | 1240 | 1250 | |
| KKMADRIRKY | QILNNEVFAI | LNKYMKSVET | DSSTVEHVRC | FQPPIHQSLA | TTC |