Q5SPD7

PR
Gene name
pycr3
Protein name
Pyrroline-5-carboxylate reductase 3
Names
P5C reductase 3, P5CR 3, Pyrroline-5-carboxylate reductase-like protein
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:560682
EC number
1.5.1.2: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-45 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5SPD7

Entry ID Method Resolution Chain Position Source
AF-Q5SPD7-F1 Predicted AlphaFoldDB

No variants for Q5SPD7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5SPD7

No associated diseases with Q5SPD7

2 regional properties for Q5SPD7

Type Name Position InterPro Accession
domain Pyrroline-5-carboxylate reductase, catalytic, N-terminal 20 - 114 IPR028939
domain Pyrroline-5-carboxylate reductase, dimerisation domain 177 - 281 IPR029036

Functions

Description
EC Number 1.5.1.2 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

1 GO annotations of molecular function

Name Definition
pyrroline-5-carboxylate reductase activity Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+.

1 GO annotations of biological process

Name Definition
L-proline biosynthetic process The chemical reactions and pathways resulting in the formation of L-proline, an L-enantiomer of a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSLSGASDKT SDSPDVFQIK IGFIGAGNMA FGVAQGIIAS GKVPPSNIII SAPSMNNLPR
70 80 90 100 110 120
FKEKGVSVTH SNHEVVGGSR LIFLAVKPHI IPQVLKEISQ EVTKEHIIVS MAAGITIATL
130 140 150 160 170 180
EELLPAGTHV IRIMPNLPCM LLEGALLLSC GSHAGEQEET LLKTLLGPCG LVEFGPESWI
190 200 210 220 230 240
DAHVGLSGSG VAFVYVFAEA LADGAVKMGM PSTLARRIAA QTILGAGVLL RDSGKLPAEL
250 260 270 280
KAEVCTPGGT TIHGIHALEK GGFRAAAIGA VEAASERARE LGNKQKKN