Q5SJX7

PR
Gene name
serS
Protein name
Serine--tRNA ligase
Names
Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase
Species
Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
KEGG Pathway
ttj:TTHA0875
EC number
6.1.1.11: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

14-107 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

6 structures for Q5SJX7

Entry ID Method Resolution Chain Position Source
3ERR X-ray 227 A PDB
8FCY EM 340 A A 31-97 PDB
8FD6 EM 290 A A 31-97 PDB
8FDT EM 320 A A 31-97 PDB
8FDU EM 330 A A 31-97 PDB
AF-Q5SJX7-F1 Predicted AlphaFoldDB

No variants for Q5SJX7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5SJX7

No associated diseases with Q5SJX7

4 regional properties for Q5SJX7

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 218 - 395 IPR002314
domain Aminoacyl-tRNA synthetase, class II 135 - 405 IPR006195
domain Serine-tRNA synthetase, type1, N-terminal 1 - 102 IPR015866
domain Serine-tRNA ligase catalytic core domain 116 - 412 IPR033729

Functions

Description
EC Number 6.1.1.11 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
serine-tRNA ligase activity Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser).

3 GO annotations of biological process

Name Definition
selenocysteine biosynthetic process The chemical reactions and pathways resulting in the formation of selenocysteine, an essential component of glutathione peroxidase and some other proteins.
selenocysteinyl-tRNA(Sec) biosynthetic process The chemical reactions and pathways resulting in the formation of selenocysteinyl-tRNA(Sec). This process occurs through the following steps: a unique serine-tRNA with a UGA recognizing anticodon is first aminoacylated with serine; this is then phosphorylated by phosphoseryl-tRNA
seryl-tRNA aminoacylation The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. The seryl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a serine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVDLKRLRQE PEVFHRAIRE KGVALDLEAL LALDQEVQEL KKRLQEVQTE RNQVAKRVPK
70 80 90 100 110 120
APPEEKEALI ARGRALGEEA KRLEEALREK EAQLEALLLQ VPLPPWPGAP VGGEEANREI
130 140 150 160 170 180
KRVGSPPEFS FPPLDHVALM EKNGWWEPRI SQVSGSRSYA LKGDLALYEL ALLRFAMDFM
190 200 210 220 230 240
ARRGFLPMTL PSYAREKAFL GTGHFPAYRD QVWAIAETDL YLTGTAEVVL NALHSGEILP
250 260 270 280 290 300
YEALPLRYAG YAPAFRSEAG SFGKDVRGLM RVHQFHKVEQ YVLTEASLEA SDRAFQELLE
310 320 330 340 350 360
NAEEILRLLE LPYRLVEVAT GDMGPGKWRQ VDVEVYLPSE GRYRETHSCS ALLDWQARRA
370 380 390 400 410 420
NLRYRDPEGR VRYAYTLNNT ALATPRILAM LLENHQLQDG RVRVPKALVP YMGKEVLEPC
G