Q5SJP8

PR
Gene name
TTHA0960
Protein name
4-hydroxyphenylacetate 3-monooxygenase oxygenase component
Names
4-HPA 3-hydroxylase, 4-HPA 3-monooxygenase large component
Species
Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
KEGG Pathway
ttj:TTHA0960
EC number
1.14.14.9: With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

32-110 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

7 structures for Q5SJP8

Entry ID Method Resolution Chain Position Source
2YYG X-ray 200 A A 1-481 PDB
2YYI X-ray 166 A A 1-481 PDB
2YYJ X-ray 166 A A 1-481 PDB
2YYK X-ray 160 A A 1-481 PDB
2YYL X-ray 175 A A 1-481 PDB
2YYM X-ray 170 A A 1-481 PDB
AF-Q5SJP8-F1 Predicted AlphaFoldDB

No variants for Q5SJP8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5SJP8

No associated diseases with Q5SJP8

2 regional properties for Q5SJP8

Type Name Position InterPro Accession
domain HpaB/PvcC/4-BUDH N-terminal 4 - 264 IPR024674
domain HpaB/PvcC/4-BUDH C-terminal 271 - 469 IPR024719

Functions

Description
EC Number 1.14.14.9 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
4-hydroxyphenylacetate 3-monooxygenase activity Catalysis of the reaction: (4-hydroxyphenyl)acetate + FADH(2) + O(2) = 3,4-dihydroxyphenylacetate + FAD + H(+) + H(2)O.
flavin adenine dinucleotide binding Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
oxidoreductase activity, acting on the CH-CH group of donors Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.

1 GO annotations of biological process

Name Definition
phenylacetate catabolic process The chemical reactions and pathways resulting in the breakdown of phenylacetate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MARTGAEYIE ALKTRPPNLW YKGEKVEDPT THPVFRGIVR TMAALYDLQH DPRYREVLTY
70 80 90 100 110 120
EEEGKRHGMS FLIPKTKEDL KRRGQAYKLW ADQNLGMMGR SPDYLNAVVM AYAASADYFG
130 140 150 160 170 180
EFAENVRNYY RYLRDQDLAT THALTNPQVN RARPPSGQPD PYIPVGVVKQ TEKGIVVRGA
190 200 210 220 230 240
RMTATFPLAD EVLIFPSTLL QAGSEKYALA FALPTSTPGL HFVCREALVG GDSPFDHPLS
250 260 270 280 290 300
SRVEEMDCLV IFDDVLVPWE RVFILGNVEL CNNAYAATGA LNHMAHQVVA LKTAKTEAFL
310 320 330 340 350 360
GVAALMAEGI GADVYGHVQE KIAEIIVYLE AMRAFWTRAE EEAKENAYGL LVPDRGALDG
370 380 390 400 410 420
ARNLYPRLYP RIREILEQIG ASGLITLPSE KDFKGPLGPF LEKFLQGAAL EAKERVALFR
430 440 450 460 470 480
LAWDMTLSGF GARQELYERF FFGDPVRMYQ TLYNVYNKEP YKERIRAFLK ESLKVFEEVQ
A