Q5RFS5
Gene name |
OCLN |
Protein name |
Occludin |
Names |
|
Species |
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) |
KEGG Pathway |
pon:100174190 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5RFS5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5RFS5-F1 | Predicted | AlphaFoldDB |
No variants for Q5RFS5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5RFS5 | |||||
No associated diseases with Q5RFS5
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| bicellular tight junction | An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| bicellular tight junction assembly | The aggregation, arrangement and bonding together of a set of components to form a tight junction, an occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSRPLESPP | PYRPDEFKPN | HYAPSNDIYG | GEMHVRPMLS | QPAYSFYPED | EILHFYKWTS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PPGVIRILSM | LIIVMCIAIF | TCVASTLAWD | RGYGTSLLGG | SIGYPYGGSG | FGSYGSGYGY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SYGYGYGYGG | YTDPRAAKGF | MLAMAAFCFI | AALVIFVTSV | IRSEMSRTRR | YYLSVIIVSA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ILGIMVFIAT | IVYIMGVNPT | AQSSGSLYGS | QIYALCNQFY | TPAATGLYVD | QYLYHYCVVD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PQEAIAIVLG | FMIIVAFALI | IFFAVKTRRK | MDRYDKSNIL | WDKEHIYDEQ | PPNVEEWVKN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VSAGTQDVPS | PPSDYVERVD | SPMAYSSNGK | VNDKRFYPES | SYKSTPVPEV | VQELPLTSPV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DDFRQPRYSS | SGNFETPSKR | APAKGRAAKS | KRTEQDHYET | DYTTGGESCD | ELEEDWIREY |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PPITSDQQRQ | LYKRNFDTGL | QEYKSLQSEL | DEINKELSRL | DKELDDYREE | SEEYMAAADE |
| 490 | 500 | 510 | 520 | ||
| YNRLKQVKGS | ADYKSKKNHC | KQLKSKLSHI | KKMVGDYDRQ | KT |