Q5RFP3

PR
Gene name
ERAP2
Protein name
Endoplasmic reticulum aminopeptidase 2
Names
Species
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
KEGG Pathway
pon:100171433
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

15-84 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5RFP3

Entry ID Method Resolution Chain Position Source
AF-Q5RFP3-F1 Predicted AlphaFoldDB

No variants for Q5RFP3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5RFP3

No associated diseases with Q5RFP3

5 regional properties for Q5RFP3

Type Name Position InterPro Accession
domain RNA recognition motif domain 39 - 117 IPR000504-1
domain RNA recognition motif domain 125 - 205 IPR000504-2
domain RNA recognition motif domain 277 - 355 IPR000504-3
domain HuB, RNA recognition motif 3 274 - 359 IPR034914
domain HuB, RNA recognition motif 2 120 - 203 IPR034999

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum membrane ; Single-pass type II membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name Definition
metalloaminopeptidase activity Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
zinc ion binding Binding to a zinc ion (Zn).

3 GO annotations of biological process

Name Definition
adaptive immune response An immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory).
antigen processing and presentation of endogenous peptide antigen via MHC class I The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules.
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLHSSAMVNS HRKSMFNIHK GFYCLAAILP QICICSQFSV PSSYHFSEDP GAFPVATNGE
70 80 90 100 110 120
RFPWQELRLP SVVIPLHYDL FVHPNLTSLD FVASEKIEVL VSNATQFIIL HSKDLEITNA
130 140 150 160 170 180
TLQSEEDSRY MKPGKELKVL SYPAHQQIAL LVPEKLMPHL KYYVAIDFQA KLGDGFEGFY
190 200 210 220 230 240
KSTYRTLGGE TRILAVTDFE PTQARMAFPC FDEPLFKANF SIKIRRESGH IALSNMPKVR
250 260 270 280 290 300
TIELEGGLLE DHFETTVKMS TYLVAYIVCD FHSVSGITSS GVKVSIYASP DKQNQTHYAL
310 320 330 340 350 360
QASLKLLDFY EKYFDIYYPL SKLDLIAIPD FASGAMENWG LITYRETSLL FDPKTSSASD
370 380 390 400 410 420
KLWVTRVIAH ELAHQWFGNL VTMEWWNDIW LKEGFAKYME LIAVNATYPE LQFDDYFLNV
430 440 450 460 470 480
CFEVITKDSL NSSRPISKPA ETPTQIQEMF DEVSYNKGAC ILNMLKDFLG EEKFQKGIIQ
490 500 510 520 530 540
YLKKFSYRNA KNDDLWSSLS NSCLESDFTS GGVCHSDPKM TSNMLTFLGE NAEVKEMMTT
550 560 570 580 590 600
WTLQKGIPLL VVKQDGCSLR LQQERFLQGV FQEDPEWRAL QERYLWHIPL TYSTSSSNVI
610 620 630 640 650 660
HRHILKSKTD TLDLPEKTSW VKFNVDSNGY YIVHYEGHGW DQLITQLNQN HTLLRPKDRV
670 680 690 700 710 720
GLIHDVFQLV GAGRLTLDKA LDMTHYLQHE TSSPALLEGL SYLELFYHMM DRRNISDISE
730 740 750 760 770 780
NLKRYLLQYF KPVIDRQSWS DEGSVWDRML RSALLKLACD LNHAPCIQKA TELFSQWMES
790 800 810 820 830 840
SGKLNIPTDV LKIVYSVGAQ TAAGWNYLLE QYELSMSSAE QNKILYALST SKHQEKLLKL
850 860 870 880 890 900
IELGMEGKVI KTQNLAALLH VIARRPKGQQ LAWDFVRENW THLLKKFDLG SFDIRMIISG
910 920 930 940 950
TTARFSSKDK LQEVKLFFES LEAQGSHLDI FQIVLETITK NIKWLEKNLP TLRTWLLVNT