Q5RF54

PR
Gene name
COPS8 (CSN8)
Protein name
COP9 signalosome complex subunit 8
Names
Signalosome subunit 8
Species
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
KEGG Pathway
pon:100171561
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

152-209 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5RF54

Entry ID Method Resolution Chain Position Source
AF-Q5RF54-F1 Predicted AlphaFoldDB

1 variants for Q5RF54

Variant ID(s) Position Change Description Diseaes Association Provenance
rs175519488 129 V>I No Ensembl

No associated diseases with Q5RF54

2 regional properties for Q5RF54

Type Name Position InterPro Accession
domain Proteasome component (PCI) domain 8 - 179 IPR000717
domain CSN8/PSMD8/EIF3K 34 - 164 IPR033464

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
COP9 signalosome A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

5 GO annotations of biological process

Name Definition
activation of NF-kappaB-inducing kinase activity The stimulation of the activity of NF-kappaB-inducing kinase through phosphorylation at specific residues.
COP9 signalosome assembly The aggregation, arrangement and bonding together of a set of components to form a COP9 signalosome.
negative regulation of cell population proliferation Any process that stops, prevents or reduces the rate or extent of cell proliferation.
protein deneddylation The removal of a ubiquitin-like protein of the NEDD8 type from a protein.
protein phosphorylation The process of introducing a phosphate group on to a protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPVAVMAESA FSFKKLLDQC ENQELEAPGG IATPPVYGQL LALYLLHNDM NNARYLWKRI
70 80 90 100 110 120
PPAIKSANSE LGGIWSVGQR IWQRDFPGIY TTINAHQWSE TVQPIMEALR DATRRRAFAL
130 140 150 160 170 180
VSQAYTSIVA DDFAAFVGLP VEEAVKGILE QGWQADSTTR MVLPRKPVAG ALDVSFNKFI
190 200
PLSEPAPVPP IPNEQQLARL TDYVAFLEN