Q5RF00

PR
Gene name
ALDH2
Protein name
Aldehyde dehydrogenase, mitochondrial
Names
ALDH class 2, ALDH-E2
Species
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
KEGG Pathway
pon:100171596
EC number
1.2.1.3: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-55 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5RF00

Entry ID Method Resolution Chain Position Source
AF-Q5RF00-F1 Predicted AlphaFoldDB

No variants for Q5RF00

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5RF00

No associated diseases with Q5RF00

No regional properties for Q5RF00

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q5RF00

Functions

Description
EC Number 1.2.1.3 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Mitochondrion matrix
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

5 GO annotations of molecular function

Name Definition
aldehyde dehydrogenase (NAD+) activity Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+.
carboxylic ester hydrolase activity Catalysis of the hydrolysis of a carboxylic ester bond.
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity Catalysis of the reaction: D-glyceraldehyde 3-phosphate + NAD+ + H2O = 3-phospho-D-glycerate + NADH + H+.
nitroglycerin reductase activity Catalysis of the removal of one or more nitrite (NO2-) groups from nitroglycerin or a derivative.
phenylacetaldehyde dehydrogenase activity Catalysis of the reaction: phenylacetaldehyde + NAD+ + H2O = phenylacetate + NADH + H+.

3 GO annotations of biological process

Name Definition
aldehyde catabolic process The chemical reactions and pathways resulting in the breakdown of aldehydes, any organic compound with the formula R-CH=O.
regulation of dopamine biosynthetic process Any process that modulates the frequency, rate or extent of dopamine biosynthetic process.
regulation of serotonin biosynthetic process Any process that modulates the frequency, rate or extent of serotonin biosynthetic process.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLRAAARFGP RLGRRLLSAA ATQAVPAPNQ QPEVFCNQIF INNEWHDAVS RKTFPTVNPS
70 80 90 100 110 120
TGEVICQVAE GDKEDVDKAV KAARAAFQLG SPWRRMDASH RGRLLNRLAD LIERDRTYLA
130 140 150 160 170 180
ALETLDNGKP YVISYLVDLD MVLKCLRYYA GWADKYHGKT IPIDGDFFSY TRHEPVGVCG
190 200 210 220 230 240
QIIPWNFPLL MQAWKLGPAL ATGNVVVMKV AEQTPLTALY VANLIKEAGF PPGVVNIVPG
250 260 270 280 290 300
FGPTAGAAIA SHEDVDKVAF TGSTEIGRVI QVAAGSSNLK RVTLELGGKS PNIIMSDADM
310 320 330 340 350 360
DWAVEQAHFA LFFNQGQCCC AGSRTFVQED IYDEFVERSV ARAKSRVVGN PFDSKTEQGP
370 380 390 400 410 420
QVDETQFKKI LGYINTGKQE GAKLLCGGGI AADRGYFIQP TVFGDVQDGM TIAKEEIFGP
430 440 450 460 470 480
VMQILKFKTI EEVVGRANNS TYGLAAAVFT KDLDKANYLS QALQAGTVWV NCYNVFGAQS
490 500 510
PFGGYKMSGS GRELGEYGLQ AYTEVKTVTV KVPQKNS