Q5REZ0

PR
Gene name
LAPTM5
Protein name
Lysosomal-associated transmembrane protein 5
Names
Lysosomal-associated multitransmembrane protein 5
Species
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
KEGG Pathway
pon:100171603
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

92-164 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5REZ0

Entry ID Method Resolution Chain Position Source
AF-Q5REZ0-F1 Predicted AlphaFoldDB

1 variants for Q5REZ0

Variant ID(s) Position Change Description Diseaes Association Provenance
rs171236350 222 V>A No Ensembl

No associated diseases with Q5REZ0

No regional properties for Q5REZ0

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q5REZ0

Functions

Description
EC Number
Subcellular Localization
  • Lysosome membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
lysosomal membrane The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
transport vesicle Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell.

2 GO annotations of molecular function

Name Definition
ubiquitin protein ligase binding Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins.
ubiquitin-dependent protein binding Binding to a protein upon ubiquitination of the target protein.

5 GO annotations of biological process

Name Definition
activation of cysteine-type endopeptidase activity involved in apoptotic process Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
defense response to tumor cell Reactions triggered in response to the presence of a tumor cell that act to protect the cell or organism.
induction of programmed cell death A process which directly activates any of the steps required for programmed cell death.
negative regulation of autophagic cell death Any process that stops, prevents or reduces the frequency, rate or extent of autophagic cell death.
positive regulation of lysosomal membrane permeability Any process that increases the frequency, rate or extent of the passage or uptake of molecules by the lysosomal membrane.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDPRLSAVRQ TCCCFNVRIA TTALAIYHVI MSVLLFIEHS VEVAHGKASC KLSQMGYLRI
70 80 90 100 110 120
ADLISSFLLI AMLFIISLSL LIGVVKNREK YLLPFLSLQV MDYLLCLLTL LGSYIELPAY
130 140 150 160 170 180
LKLASRSRAS PSKFPLMTLQ LLDFCLSILT LCSSYMEVPT YLNFKSMNHM NYLPSQEDMP
190 200 210 220 230 240
HNQFIKMMII FSIAFITVLI FKVYMFKCVW RCYRFIKCMN SVEEKRNSKM LQKVVLPSYE
250 260
EALSLPSKTP EGGPAPPPYS EV