Q5RET2

PR
Gene name
FKBP7
Protein name
Peptidyl-prolyl cis-trans isomerase FKBP7
Names
PPIase FKBP7, FK506-binding protein 7, FKBP-7, Rotamase
Species
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
KEGG Pathway
pon:100171639
EC number
5.2.1.8: Cis-trans isomerases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-73 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5RET2

Entry ID Method Resolution Chain Position Source
AF-Q5RET2-F1 Predicted AlphaFoldDB

No variants for Q5RET2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5RET2

No associated diseases with Q5RET2

4 regional properties for Q5RET2

Type Name Position InterPro Accession
domain FKBP-type peptidyl-prolyl cis-trans isomerase domain 47 - 145 IPR001179
domain EF-hand domain 189 - 222 IPR002048
binding_site EF-Hand 1, calcium-binding site 158 - 170 IPR018247-1
binding_site EF-Hand 1, calcium-binding site 202 - 214 IPR018247-2

Functions

Description
EC Number 5.2.1.8 Cis-trans isomerases
Subcellular Localization
  • Endoplasmic reticulum lumen
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
endoplasmic reticulum lumen The volume enclosed by the membranes of the endoplasmic reticulum.

2 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).
peptidyl-prolyl cis-trans isomerase activity Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPKTMHFLFR FIVFFYLWGL FTAQRQKKEE RTEEVKIEVL HRPENCSKTS KKGDLLNAHY
70 80 90 100 110 120
DGYLAKDGSK FYCSRTQNEG HPKWFVLGVG QVIKGLDIAM TDMCPGEKRK VVIPPSFAYG
130 140 150 160 170 180
KEGYAEGKIP PDATLIFEIE LYAVTKGPRS TETFKQIDMD SDRQLSKAEI NLYLQREFEK
190 200 210 220
DEKPRDKSYQ DAVLEDIFKK NDHDGDGFIS PKEYNVYQHD EL