Q5REP0

PR
Gene name
BCAT2
Protein name
Branched-chain-amino-acid aminotransferase, mitochondrial
Names
BCAT(m)
Species
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
KEGG Pathway
pon:100171664
EC number
2.6.1.42: Transaminases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

3-76 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5REP0

Entry ID Method Resolution Chain Position Source
AF-Q5REP0-F1 Predicted AlphaFoldDB

No variants for Q5REP0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5REP0

No associated diseases with Q5REP0

1 regional properties for Q5REP0

Type Name Position InterPro Accession
conserved_site Aminotransferase, class IV, conserved site 264 - 298 IPR018300

Functions

Description
EC Number 2.6.1.42 Transaminases
Subcellular Localization
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

4 GO annotations of molecular function

Name Definition
L-isoleucine transaminase activity Catalysis of the reaction: 2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoic acid + L-glutamic acid.
L-leucine transaminase activity Catalysis of the reaction: 2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamatic acid.
L-leucine:2-oxoglutarate aminotransferase activity Catalysis of the reaction: L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate.
L-valine transaminase activity Catalysis of the reaction: 2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoic acid + L-glutamatic acid.

3 GO annotations of biological process

Name Definition
branched-chain amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine.
cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents.
lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAAAALGQIW ARKFLSVPWL LCGPRRYASS SFKAADLQLE MTQKPHKKPG PGEPLVFGKT
70 80 90 100 110 120
FTDHMLMVEW SDKGWGQPRI QPFQNLTLHP ASSSLHYSLQ LFEGMKAFKG KDQQVRLFRP
130 140 150 160 170 180
WLNMDRMLRS AMRLCLPSFD KLELLECIRR LIEVDKDWVP DAAGTSLYVR PVLIGNEPSL
190 200 210 220 230 240
GVSQPTRALL FVILCPVGTY FPGGSVTPVS LLADPAFIRA WVGGVGNYKL GGNYGPTVLV
250 260 270 280 290 300
QQEALKQGCE QVLWLYGPDH QLTEVGTMNI FVYWTHEDGV LELVTPPLNG VILPGVVRQS
310 320 330 340 350 360
LLDLAQTWGE FRVVERTITT KQLLQALEEG RVREVFGSGT ACQVCPVHRI LYKDRNLHIP
370 380 390
TMENGPELIL RFQKELKEIQ YGIRAHEWMF PV