Q5REK3

PR
Gene name
PMPCB
Protein name
Mitochondrial-processing peptidase subunit beta
Names
Beta-MPP
Species
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
KEGG Pathway
pon:100174253
EC number
3.4.24.64: Metalloendopeptidases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

4-83 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5REK3

Entry ID Method Resolution Chain Position Source
AF-Q5REK3-F1 Predicted AlphaFoldDB

No variants for Q5REK3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5REK3

No associated diseases with Q5REK3

3 regional properties for Q5REK3

Type Name Position InterPro Accession
binding_site Peptidase M16, zinc-binding site 88 - 111 IPR001431
domain Peptidase M16, C-terminal 220 - 404 IPR007863
domain Peptidase M16, N-terminal 68 - 214 IPR011765

Functions

Description
EC Number 3.4.24.64 Metalloendopeptidases
Subcellular Localization
  • Mitochondrion matrix
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mitochondrial processing peptidase complex A protein complex consisting of a regulatory subunit (alpha-MPP) and a catalytic subunit (beta-MPP) that catalyzes the release of N-terminal targeting peptides from precursor proteins imported into the mitochondrion.

2 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
metalloendopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

1 GO annotations of biological process

Name Definition
protein processing involved in protein targeting to mitochondrion The cleavage of peptide bonds in proteins, usually near the N terminus, contributing to the process of import into the mitochondrion. Several different peptidases mediate cleavage of proteins destined for different mitochondrial compartments.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAAAAARVVL LPAARRRLWG FSESLLIRGA AGRSSYFGEN RLRSTQAATQ VVLNVPETRV
70 80 90 100 110 120
TCLESGLRVA SEDSGLSTCT VGLWIDAGSR YENEKNNGTA HFLEHMAFKG TKKRSQLDLE
130 140 150 160 170 180
LEIENMGAHL NAYTSREQTV YYAKAFSKDL PRAVEILADI IQNSTLGEAE IERERGVILR
190 200 210 220 230 240
EMQEVETNLQ EVVFDYLHAT AYQNTALGRT ILGPTENIKS ISRKDLVDYI TTHYKGPRIV
250 260 270 280 290 300
LAAAGGVSHD ELLDLAKFHF GDSLCTHKGE IPALPPCKFT GSEIRVRDDK MPLAHLAIAV
310 320 330 340 350 360
EAVGWAHPDT ICLMVANTLI GNWDRSFGGG MNLSSKLAQL TCHGNLCHSF QSFNTSYTDT
370 380 390 400 410 420
GLWGLYMVCE PSTVADMLHV VQKEWMRLCT SVTESEVARA RNLLKTNMLL QLDGSTPICE
430 440 450 460 470 480
DIGRQMLCYN RRIPIPELEA RIDAVNAETI REVCTKYIYN RSPAIAAVGP IEQLPDFKQI
CSNMCWLRD