Q5REF9

PR
Gene name
TYW1 (RSAFD1)
Protein name
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1
Names
Radical S-adenosyl methionine and flavodoxin domain-containing protein 1, tRNA wybutosine-synthesizing protein 1 homolog, tRNA-yW-synthesizing protein
Species
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
KEGG Pathway
pon:100171721
EC number
4.1.3.44: Oxo-acid-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

22-100 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5REF9

Entry ID Method Resolution Chain Position Source
AF-Q5REF9-F1 Predicted AlphaFoldDB

2 variants for Q5REF9

Variant ID(s) Position Change Description Diseaes Association Provenance
rs178046100 74 V>I No Ensembl
rs178046162 216 D>N No Ensembl

No associated diseases with Q5REF9

3 regional properties for Q5REF9

Type Name Position InterPro Accession
domain Aldehyde dehydrogenase domain 11 - 473 IPR015590
conserved_site Aldehyde dehydrogenase, cysteine active site 274 - 285 IPR016160
conserved_site Aldehyde dehydrogenase, glutamic acid active site 246 - 253 IPR029510

Functions

Description
EC Number 4.1.3.44 Oxo-acid-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
FMN binding Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
metal ion binding Binding to a metal ion.
tRNA-4-demethylwyosine synthase activity Catalysis of the reaction: pyruvate + S-adenosyl-L-methionine + N1-methylguanine37 in tRNAPhe = L-methionine + 5'-deoxyadenosine + carbon dioxide + H2O + 4-demethylwyosine37 in tRNAPhe.

1 GO annotations of biological process

Name Definition
tRNA processing The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDPSMDTWDL SSPLISLWIN RFYIYLGFAV SISLWICVQI VIKTQGRNLQ EKSVPKAAQD
70 80 90 100 110 120
LMTNGYVSLQ EKDVFVSGVK IFYGSQTGTA KGFATVLAEA VTSLDLPVAI INLKEYDPDD
130 140 150 160 170 180
HLIEEVTSKN VCVFLVATYT DGLPTESAEW FCKWLEEAAI DFRFGKTYLK GMRYAVFGLG
190 200 210 220 230 240
NSAYASHFNK VGKNVDKWLW MLGAHRVMSR GEGDCDVVKS KHGSIEADFR AWKTKFISQL
250 260 270 280 290 300
QALQKGERKK SCGGHCKKGK CESHQRGSEE REEGSHEQDE LHHRDTEEEE PFESSSEEEF
310 320 330 340 350 360
GGKDHQSLNS IVDVEDLGKI MDHVKKEKRE KEQREEKSGL FRNMGRNEDG EIRAMITPAL
370 380 390 400 410 420
REALTKQGYQ LIGSHSGVKL CRWTKSMLRG RGGCYKHTFY GIESHRCMET TPSLACANKC
430 440 450 460 470 480
VFCWRHHTNP VGTEWRWKMD QPEMILKEAI ENHQNMIKQF KGVPGVKAER FEEGMTVKHC
490 500 510 520 530 540
ALSLVGEPIM YPEINRFLKL LHQCKISSFL VTNAQFPAEI RNLEPVTQLY VSVDASTKDS
550 560 570 580 590 600
LKKIDRPLFK DFWRRFLDSL KALAVKQQRT VYRLTLVKAW NVDELQAYAQ LVSLGNPDFI
610 620 630 640 650 660
EVKGVTYCGE SSASSLTMAH VPWHEEVVQF VCELVDLIPD YEIACEHEHS NCLLIAHKKF
670 680 690 700 710 720
KIGGEWWTWI DYNRFQELIQ EYEDSSGSKT FSAKDYMART PHWALFGANE RGFDPKDTRH
730
QRKNKSKAIS GC