Q5RDL2

PR
Gene name
DDX24
Protein name
ATP-dependent RNA helicase DDX24
Names
DEAD box protein 24
Species
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
KEGG Pathway
pon:100171919
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

35-209 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5RDL2

Entry ID Method Resolution Chain Position Source
AF-Q5RDL2-F1 Predicted AlphaFoldDB

2 variants for Q5RDL2

Variant ID(s) Position Change Description Diseaes Association Provenance
rs173199591 463 R>L No Ensembl
rs173199590 583 L>M No Ensembl

No associated diseases with Q5RDL2

3 regional properties for Q5RDL2

Type Name Position InterPro Accession
repeat HEAT repeat 395 - 425 IPR000357
domain TOG domain 352 - 581 IPR034085
repeat Importin repeat 4 266 - 338 IPR041653

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKLKDTKSRP KQSSYGKFQT KGIKVVGKWK EVKIDPNMFA DGQMDDLVCF EELTDYQLVS
70 80 90 100 110 120
PAKNPSSLFS KEAPKRKAQA VSEEEEEEEG ESSSPKKKIK LKKSKNVATE GTSTQKEFEV
130 140 150 160 170 180
KDPELEAQGD GMVCDDPEAG EMTSENLVQT APKKKKNKAK KGLEPSQSTA AKVPKKAKTW
190 200 210 220 230 240
IPEVHDQKAD VSAWKDLFVP RPVLRALSFL GFSAPTPIQV LTLAPAIRDK LDILGAAETG
250 260 270 280 290 300
SGKTLAFAIP MIHAVLQWQK RNAAPPPSNT EAPPGETRPE AGAETRSPGK AEAESDALPD
310 320 330 340 350 360
DTVIESEALP SDTAAEARAK TGGTVSDQAL LFGDDDAGEG PSSLIREKPV PKQNENEEEN
370 380 390 400 410 420
LDKEQTGNLK QELDDKSATC KTYPKRPLLG LVLTPTRELA VQVKQHIDAV ARFTGIKTAI
430 440 450 460 470 480
LVGGMSTQKQ QRMLNRRPEI VVATPGRLWE LIKEKHYHLR NLRQLRCLVV DEADRMVEKG
490 500 510 520 530 540
HFAELSQLLE MLNDSQYNPK RQTLVFSATL TLVHQAPARI LHKKHTKKMD KTAKLDLLMQ
550 560 570 580 590 600
KIGMRGKPKV IDLTRNEATV ETLTETKIHC ETDEKDFYLY YFLMQYPGRS LVFANSISCI
610 620 630 640 650 660
KRLSGLLKVL DIMPLTLHAC MHQKQRLRNL EQFARLEDCV LLATDVAARG LDIPKVQHVI
670 680 690 700 710 720
HYQVPRTSEI YVHRSGRTAR ATNEGLSLML IGPEDVINFK KIYKTLKKDE DIPLFPVQTK
730 740 750 760 770 780
YMDVVKERIR LARQIEKSEY RNFQACLHNS WIEQAAAALE IELEEDMYKG GKADQQEERR
790 800 810 820 830 840
RQKQMKVLKK ELRHLLSQPL FTESQKTKYP TQSGKPPLLV SAPSKSESAL SCLSKQRKKK
850
TKKPKEPQPE QPQPSTSAN