Q5RCW2

PR
Gene name
PNPT1 (PNPASE)
Protein name
Polyribonucleotide nucleotidyltransferase 1, mitochondrial
Names
Polynucleotide phosphorylase 1, PNPase 1
Species
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
KEGG Pathway
pon:100172084
EC number
2.7.7.8: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

723-783 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5RCW2

Entry ID Method Resolution Chain Position Source
AF-Q5RCW2-F1 Predicted AlphaFoldDB

No variants for Q5RCW2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5RCW2

No associated diseases with Q5RCW2

8 regional properties for Q5RCW2

Type Name Position InterPro Accession
domain Exoribonuclease, phosphorolytic domain 1 54 - 183 IPR001247-1
domain Exoribonuclease, phosphorolytic domain 1 367 - 501 IPR001247-2
domain S1 domain 679 - 750 IPR003029
domain K Homology domain 604 - 669 IPR004087
domain K Homology domain, type 1 608 - 665 IPR004088
domain Exoribonuclease, phosphorolytic domain 2 186 - 250 IPR015847
domain Polyribonucleotide nucleotidyltransferase, RNA-binding domain 283 - 363 IPR015848
domain RNA-binding domain, S1 677 - 750 IPR022967

Functions

Description
EC Number 2.7.7.8 Nucleotidyltransferases
Subcellular Localization
  • Cytoplasm
  • Mitochondrion matrix
  • Mitochondrion intermembrane space ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
mitochondrial degradosome A mitochondrial protein complex with 3' to 5' exoribonuclease activity that participates in intron-independent turnover and processing of mitochondrial transcripts. In humans, the mitochondrial degradosome is a pentameric complex, and in yeast it exists as a heterodimer.
mitochondrial intermembrane space The region between the inner and outer lipid bilayers of the mitochondrial envelope.
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

5 GO annotations of molecular function

Name Definition
3'-5'-exoribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule.
miRNA binding Binding to a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes.
poly(G) binding Binding to a sequence of guanine residues in an RNA molecule.
poly(U) RNA binding Binding to a sequence of uracil residues in an RNA molecule.
polyribonucleotide nucleotidyltransferase activity Catalysis of the reaction: RNA(n+1) + phosphate <=> RNA(n) + a nucleoside diphosphate.

22 GO annotations of biological process

Name Definition
cellular response to oxidative stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
mitochondrial mRNA catabolic process The chemical reactions and pathways resulting in the breakdown of mRNA transcribed from the mitochondrial genome and occurring in the mitochondrion.
mitochondrial mRNA polyadenylation The enzymatic addition of a sequence of 40-60 adenylyl residues at the 3' end of a eukaryotic mitochondrial mRNA primary transcript. Mitochondria contain both stabilizing and destabilizing poly(A) tails.
mitochondrial RNA 3'-end processing Any process involved in forming the mature 3' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion.
mitochondrial RNA 5'-end processing Any process involved in forming the mature 5' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion.
mitochondrial RNA catabolic process The chemical reactions and pathways resulting in the breakdown of RNA transcribed from the mitochondrial genome and occurring in the mitochondrion.
mitochondrion morphogenesis The process in which the anatomical structures of a mitochondrion are generated and organized.
mRNA catabolic process The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
negative regulation of growth Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism.
nuclear polyadenylation-dependent mRNA catabolic process The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a messenger RNA (mRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target mRNA.
positive regulation of miRNA catabolic process Any process that activates or increases the frequency, rate or extent of miRNA catabolic process.
positive regulation of mitochondrial RNA catabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome.
positive regulation of mRNA catabolic process Any process that increases the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
protein homotrimerization The formation of a protein homotrimer, a macromolecular structure consisting of three noncovalently associated identical subunits.
regulation of cell cycle Any process that modulates the rate or extent of progression through the cell cycle.
regulation of cellular respiration Any process that modulates the frequency, rate or extent of cellular respiration, the enzymatic release of energy from organic compounds.
regulation of cellular senescence Any process that modulates the frequency, rate or extent of cellular senescence.
RNA catabolic process The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
RNA import into mitochondrion The process in which a rRNA, ribosomal ribonucleic acid, is transported from the cytosol into the mitochondrial matrix.
RNA polyadenylation The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule.
rRNA import into mitochondrion The process in which a rRNA, ribosomal ribonucleic acid, transported from the cytosol into the mitochondrial matrix.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAACRYCCSC LRLRPLSDGP FCLPGRDRAL TQLLVRALWS STGSRAVAVD LGNRKLEISS
70 80 90 100 110 120
GKLARFADGS AVVQSGDTAV MVTAVSKTKP SPSQFMPLVV DYRQKAAAAG RIPTNYLRRE
130 140 150 160 170 180
IGTSDKEILT SRIIDRSIRP LFPAGYFYDT QVLCNLLAVD GVNEPDVLAI NGASVALSLS
190 200 210 220 230 240
DIPWNGPVGA VRIGIIDGEC VVNPTRKEMS SSTLNLVVAG APKSQIVMLE ASAENILQQD
250 260 270 280 290 300
FCHAIKVGVK YTQQIIQGIQ QLVKETGVTK RTPQKLFTPS PEIVKHTHKL AMERLYAVFT
310 320 330 340 350 360
DYEHDKVSRD EAVNKIRLDT EEQLKEKFPQ ADPYEIIESF NVVAKEVFRN IILNEYKRCD
370 380 390 400 410 420
GRDLTSLRNV SCEVDMFKTL HGSALFQRGQ TQVLCTVTFD SLESGIKSDQ VITAINGIKD
430 440 450 460 470 480
KNFMLHYEFP PYATNEIGKV TGLNRRELGH GALAEKALYP VIPRDFPFTI RVTSEVLESN
490 500 510 520 530 540
GSSSMASACG GSLALMDSGV PISSAVAGVA IGLVTKTDPE KGEIEDYRLL TDILGIEDYN
550 560 570 580 590 600
GDMDFKIAGT NKGITALQAD IKLPGIPIKI VMEAIQQASV AKKEILQIMN KTISKPRTSR
610 620 630 640 650 660
KENGPVVETV QVPLSKRAKF VGPGGYNLKK LQAETGVTIS QVDEETFSVF APTPSALHEA
670 680 690 700 710 720
RDFITEICKD DQEQQLEFGA VYTATITEIR DTGVMVKLYP NMTAVLLHNT QLDQRKIRHP
730 740 750 760 770 780
TALGLEVGQE IQVKYFGRDP ADGRMRLSRK VLQSPATTVV RTLNDRSSIV MGEPISQSSS
NSQ