Q5RCU3

PR
Gene name
NAPEPLD
Protein name
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D
Names
N-acyl phosphatidylethanolamine phospholipase D, NAPE-PLD, NAPE-hydrolyzing phospholipase D
Species
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
KEGG Pathway
pon:100172099
EC number
3.1.4.54: Phosphoric diester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-193 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5RCU3

Entry ID Method Resolution Chain Position Source
AF-Q5RCU3-F1 Predicted AlphaFoldDB

No variants for Q5RCU3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5RCU3

No associated diseases with Q5RCU3

1 regional properties for Q5RCU3

Type Name Position InterPro Accession
domain Homeobox domain 100 - 160 IPR001356

Functions

Description
EC Number 3.1.4.54 Phosphoric diester hydrolases
Subcellular Localization
  • Golgi apparatus membrane ; Peripheral membrane protein
  • Early endosome membrane ; Peripheral membrane protein
  • Nucleus envelope
  • Nucleus, nucleoplasm
  • Localized in the proximity of the cellular membranes likely through interaction with membrane phospholipids
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
early endosome A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
early endosome membrane The lipid bilayer surrounding an early endosome.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
nuclear envelope The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.

3 GO annotations of molecular function

Name Definition
N-acetylphosphatidylethanolamine-hydrolysing phospholipase activity Catalysis of the reaction: H2O + an N-acylphosphatidylethanolamine = H+ + an N-acylethanolamine + a 1,2-diacyl-sn-glycerol 3-phosphate.
N-acylphosphatidylethanolamine-specific phospholipase D activity Catalysis of the release of N-acylethanolamine from N-acyl-phosphatidylethanolamine (NAPE) to generate N-acylethanolamine (NAE).
zinc ion binding Binding to a zinc ion (Zn).

6 GO annotations of biological process

Name Definition
host-mediated regulation of intestinal microbiota composition The biological process involved in maintaining the steady-state number of cells within a population of free-living cells such as the bacteria in the gut.
N-acylphosphatidylethanolamine metabolic process The chemical reactions and pathways involving N-acylphosphatidylethanolamines. An N-acylphosphatidylethanolamine is a phosphatidylethanolamine substituted at nitrogen by an acyl group.
phospholipid catabolic process The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester.
positive regulation of brown fat cell differentiation Any process that increases the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria.
positive regulation of inflammatory response Any process that activates or increases the frequency, rate or extent of the inflammatory response.
temperature homeostasis A homeostatic process in which an organism modulates its internal body temperature.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDENESNQSL MTSSQYPKEA VRKRQNSARN SGGSDSSRFS RKSFKLDYRL EEDVTKSKKG
70 80 90 100 110 120
KDGRFVNPWP TWKNHSIPHV LRWLIMEKDH SSVPSSKEEL DKELPVLKPY FITNPEEAGV
130 140 150 160 170 180
RETGLRVTWL GHATVMVEMD ELIFLTDPIF SSRASPSQYM GPKRFRRSPC TISELPPIDA
190 200 210 220 230 240
VLISHNHYDH LDYNSVIALN ERFGNELRWF VPLGLLDWMQ KCGCENVIEL DWWEENCVPG
250 260 270 280 290 300
HDKVTFVFTP SQHWCKRTLM DDNKVLWGSW SVLGPWNRFF FAGDTGYCPA FEEIGKRFGP
310 320 330 340 350 360
FDLAAIPIGA YEPRRFMKYQ HVDPEEAVRI HIDVQTKKSM AIHWGTFALA NEHYLEPPVK
370 380 390
LNEALERYGL NAEDFFVLKH GESRYLNTDD ENF