Q5RCS8

PR
Gene name
ATP6V1D
Protein name
V-type proton ATPase subunit D
Names
V-ATPase subunit D, Vacuolar proton pump subunit D
Species
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
KEGG Pathway
pon:100172107
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

174-247 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5RCS8

Entry ID Method Resolution Chain Position Source
AF-Q5RCS8-F1 Predicted AlphaFoldDB

No variants for Q5RCS8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5RCS8

No associated diseases with Q5RCS8

No regional properties for Q5RCS8

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q5RCS8

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Peripheral membrane protein
  • Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
  • Cell projection, cilium
  • Localizes to centrosome and the base of the cilium
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
centrosome A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
cilium A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
clathrin-coated vesicle membrane The lipid bilayer surrounding a clathrin-coated vesicle.
vacuolar proton-transporting V-type ATPase, V1 domain The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane.

1 GO annotations of molecular function

Name Definition
proton-transporting ATPase activity, rotational mechanism Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism.

2 GO annotations of biological process

Name Definition
cilium assembly The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
protein localization to cilium A process in which a protein is transported to, or maintained in, a location within a cilium.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSGKDRIEIF PSRMAQTIMK ARLKGAQTGR NLLKKKSDAL TLRFRQILKK IIETKMLMGE
70 80 90 100 110 120
VMREAAFSLA EAKFTAGDFS TTVIQNVNKA QVKIRAKKDN VAGVTLPVFE HYHEGTDSYE
130 140 150 160 170 180
LTGLARGGEQ LAKLKRNYAK AVELLVELAS LQTSFVTLDE AIKITNRRVN AIEHVIIPRI
190 200 210 220 230 240
ERTLAYIITE LDEREREEFY RLKKIQEKKK ILKEKSEKDL EQRRAAGEVL EPANLLAEEK
DEDLLFE