Q5RCK6

PR
Gene name
SYT10
Protein name
Synaptotagmin-10
Names
Synaptotagmin X, SytX
Species
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
KEGG Pathway
pon:100172160
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

71-258 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5RCK6

Entry ID Method Resolution Chain Position Source
AF-Q5RCK6-F1 Predicted AlphaFoldDB

No variants for Q5RCK6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5RCK6

No associated diseases with Q5RCK6

6 regional properties for Q5RCK6

Type Name Position InterPro Accession
domain C2 domain 231 - 352 IPR000008-1
domain C2 domain 363 - 496 IPR000008-2
domain Synaptotagmin 235 - 250 IPR001565-1
domain Synaptotagmin 250 - 263 IPR001565-2
domain Synaptotagmin 305 - 320 IPR001565-3
domain Synaptotagmin 325 - 335 IPR001565-4

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasmic vesicle, secretory vesicle membrane ; Single-pass membrane protein
  • Localizes to neuronal vesicles containing IGF1 that are not enriched at synapses
  • Does not colocalize with synaptic vesicles or with the Golgi apparatus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
exocytic vesicle A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
synapse The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
transport vesicle membrane The lipid bilayer surrounding a transport vesicle.

1 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).

4 GO annotations of biological process

Name Definition
chemical synaptic transmission The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
exocytosis A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.
positive regulation of calcium ion-dependent exocytosis Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis.
sensory perception of smell The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSFHKEDGVN SLCQKALHIV TELCFAGQVE WEKCSGIFPR DRGSQGGSST DISVSLLAVV
70 80 90 100 110 120
VSFCGLALLV VSLFVFWKLC WPCWKSKPVT SNITTLPQSI SSAPTEVFET EEKKEIKENE
130 140 150 160 170 180
KPAMKAIEPA IKISHTSPDI PAEVQTALKE HLIKHARVQR QITEPTSSSR HNSFRRHLPR
190 200 210 220 230 240
QMQVSSVDFS MGTEPVLQRG ETTTSIGRIK PELYKQKSVD SEGNQKEDVK ICGKLNFTLQ
250 260 270 280 290 300
YDYENELLVV KIIKALDLPA KDFTGTSDPY VKMYLLPDRK KKFQTRVHRK TLNPLFDETF
310 320 330 340 350 360
QFPVAYDQLS NRKLHFSVYD FDRFSRHDMI GEVILDNLFE VSDLSREATV WKDIHCATTE
370 380 390 400 410 420
SIDLGEIMFS LCYLPTAGRM TLTVIKCRNL KAMDITGSSD PYVKVSLMCE GRRLKKRKTT
430 440 450 460 470 480
TKKNTLNPVY NEAIIFDIPP ENVDQVSLSI AVMDYDRVGH NEVIGVCRTG LDAEGLGRDH
490 500 510 520
WNEMLAYHRK PITHWHPLLE LPGRATSFDS QGSCPSPKPP STP