Q5RCC2
Gene name |
PRPF6 |
Protein name |
Pre-mRNA-processing factor 6 |
Names |
PRP6 homolog, U5 snRNP-associated 102 kDa protein, U5-102 kDa protein |
Species |
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) |
KEGG Pathway |
pon:100172214 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5RCC2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5RCC2-F1 | Predicted | AlphaFoldDB |
No variants for Q5RCC2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5RCC2 | |||||
No associated diseases with Q5RCC2
16 regional properties for Q5RCC2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | HAT (Half-A-TPR) repeat | 289 - 321 | IPR003107-1 |
| repeat | HAT (Half-A-TPR) repeat | 323 - 355 | IPR003107-2 |
| repeat | HAT (Half-A-TPR) repeat | 384 - 416 | IPR003107-3 |
| repeat | HAT (Half-A-TPR) repeat | 417 - 446 | IPR003107-4 |
| repeat | HAT (Half-A-TPR) repeat | 447 - 476 | IPR003107-5 |
| repeat | HAT (Half-A-TPR) repeat | 554 - 586 | IPR003107-6 |
| repeat | HAT (Half-A-TPR) repeat | 588 - 620 | IPR003107-7 |
| repeat | HAT (Half-A-TPR) repeat | 622 - 654 | IPR003107-8 |
| repeat | HAT (Half-A-TPR) repeat | 656 - 687 | IPR003107-9 |
| repeat | HAT (Half-A-TPR) repeat | 689 - 721 | IPR003107-10 |
| repeat | HAT (Half-A-TPR) repeat | 723 - 755 | IPR003107-11 |
| repeat | HAT (Half-A-TPR) repeat | 757 - 789 | IPR003107-12 |
| repeat | HAT (Half-A-TPR) repeat | 791 - 823 | IPR003107-13 |
| domain | PRP1 splicing factor, N-terminal | 13 - 169 | IPR010491 |
| repeat | Tetratricopeptide repeat | 709 - 742 | IPR019734-1 |
| repeat | Tetratricopeptide repeat | 841 - 874 | IPR019734-2 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| nuclear speck | A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. |
| U2-type precatalytic spliceosome | A spliceosomal complex that is formed by the recruitment of the preassembled U4/U6.U5 tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U1, U2 and U4/U6.U5 snRNPs. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| mRNA splicing, via spliceosome | The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNKKKKPFLG | MPAPLGYVPG | LGRGATGFTT | RSDIGPARDA | NDPVDDRHAP | PGKRTVGDQM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KKNQAADDDD | EDLNDTNYDE | FNGYAGSLFS | SGPYEKDDEE | ADAIYAALDK | RMDERRKERR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EQREKEEIEK | YRMERPKIQQ | QFSDLKRKLA | EVTEEEWLSI | PEVGDARNKR | QRNPRYEKLT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PVPDSFFAKH | LQTGENHTSV | DPRQTQFGGL | NTPYPGGLNT | PYPGGMTPGL | MTPGTGELDM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RKIGQARNTL | MDMRLSQVSD | SVSGQTVVDP | KGYLTDLNSM | IPTHGGDIND | IKKARLLLKS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VRETNPHHPP | AWIASARLEE | VTGKLQVARN | LIMKGTEMCP | KSEDVWLEAA | RLQPGDTAKA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VVAQAVRHLP | QFVRIYIRAA | ELETDIRAKK | RVLRKALEHV | PNSVRLWKAA | VELEEPEDAR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| IMLSRAVECC | PTSVELWLAL | ARLETYENAR | KVLNKARENI | PTDRHIWITA | AKLEEANGNT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QMVEKIIDRA | ITSLRANGVE | INREQWIQDA | EECDRAGSVA | TCQAVMRAVI | GIGIEEEDRK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| HTWMEDADSC | VAHNALECAR | AIYAYALQVF | PSKKSVWLRA | AYFGKNHGTR | ESLEALLQRA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| VAHCPKAEVL | WLMGAKSKWL | TGDVPAARSI | LALAFQANPN | SEEIWLAAVK | LESENDEYER |
| 670 | 680 | 690 | 700 | 710 | 720 |
| ARRLLAKARS | SAPTARVFMK | SVKLEWVQDN | IRAAQDLCEE | ALRHYEDFPK | LWMMKGQIEE |
| 730 | 740 | 750 | 760 | 770 | 780 |
| QKEMMEKARE | AYNQGLKKCP | HSTPLWLLLS | RLEEKIGQLT | RTRAILEKSR | LKNPKNPGLW |
| 790 | 800 | 810 | 820 | 830 | 840 |
| LESVRLEYRA | GLKNIANTLM | AKALQECPNS | GILWSEAIFL | EARPQRRTKS | VDALKKCEHD |
| 850 | 860 | 870 | 880 | 890 | 900 |
| PHVLLAVAKL | FWSQRKITKA | REWFHRTVKI | DSDLGDAWAF | FYKFELQHGT | EERQEEVRKR |
| 910 | 920 | 930 | 940 | ||
| CESAEPRHGE | LWCAVSEDIA | NWQKKIGDIL | RLVAGRIKNT | F |