Q5RBL4

PR
Gene name
FLOT1
Protein name
Flotillin-1
Names
Species
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
KEGG Pathway
pon:100172392
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

140-423 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5RBL4

Entry ID Method Resolution Chain Position Source
AF-Q5RBL4-F1 Predicted AlphaFoldDB

No variants for Q5RBL4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5RBL4

No associated diseases with Q5RBL4

2 regional properties for Q5RBL4

Type Name Position InterPro Accession
domain Band 7 domain 6 - 266 IPR001107
domain Flotillin, C-terminal domain 310 - 389 IPR031905

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Peripheral membrane protein
  • Endosome
  • Membrane, caveola ; Peripheral membrane protein
  • Melanosome
  • Membrane raft
  • Identified by mass spectrometry in melanosome fractions from stage I to stage IV (By similarity)
  • Membrane-associated protein of caveola (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
endosome A vacuole to which materials ingested by endocytosis are delivered.
flotillin complex A protein complex that contains flotillin-1 and flotillin-2, and may contain associated proteins. Flotillins associate into membrane microdomains resembling caveolae.
melanosome A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells.
membrane raft Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFFTCGSNEA MVVSGFCRSP PVMVAGGRVF VLPCIQQIQR ISLNTLTLNV KSEKVYTRHG
70 80 90 100 110 120
VPISVTGIAQ VKIQGQNKEM LAAACQMFLG KTEAEIAHIA LETLEGHQRA IMAHMTVEEI
130 140 150 160 170 180
YKDRQKFSEQ VFKVASSDLV NMGISVVSYT LKDIHDDQDY LHSLGKARTA QVQKDARIGE
190 200 210 220 230 240
AEAKRDAGIR EAKAKQEKVS AQYLSEIEMA KAQRDYELKK AAYDIEVNTR RAQADLAYQL
250 260 270 280 290 300
QVAKTKQQIE EQRVQVQVVE RAQQVAVQEQ EIARREKELE ARVRKPAEAE RYKLERLAEA
310 320 330 340 350 360
EKSQLIMQAE AEAESVRMRG EAEAFAIGAR ARAEAEQMAK KAEAFQLYQE AAQLDMLLEK
370 380 390 400 410 420
LPQVAEEISG PLTSANKITL ASSGSGTMGA AKVTGEVLDI LTRLPESVER LTGVSISQVN
HKPLRTA