Q5RBG3

PR
Gene name
NSFL1C
Protein name
NSFL1 cofactor p47
Names
p97 cofactor p47
Species
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
KEGG Pathway
pon:100172420
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

16-319 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5RBG3

Entry ID Method Resolution Chain Position Source
AF-Q5RBG3-F1 Predicted AlphaFoldDB

1 variants for Q5RBG3

Variant ID(s) Position Change Description Diseaes Association Provenance
rs174431436 310 Q>K No Ensembl

No associated diseases with Q5RBG3

3 regional properties for Q5RBG3

Type Name Position InterPro Accession
domain Neutral trehalase Ca2+ binding 93 - 122 IPR011120
conserved_site Glycoside hydrolase, family 37, conserved site 286 - 299 IPR018232-1
conserved_site Glycoside hydrolase, family 37, conserved site 609 - 618 IPR018232-2

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Golgi apparatus, Golgi stack
  • Chromosome
  • Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
  • Predominantly nuclear in interphase cells
  • Bound to the axial elements of sex chromosomes in pachytene spermatocytes
  • A small proportion of the protein is cytoplasmic, associated with Golgi stacks
  • Localizes to centrosome during mitotic prophase and metaphase
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
Golgi stack The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack.
microtubule organizing center An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name Definition
lipid binding Binding to a lipid.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAAERQEALR EFVAVTGAEE DRARFFLESA GWDLQIALAS FYEDGGDEDI VTISQATPSS
70 80 90 100 110 120
VSRGTAPSDN RVTSFRDLIH DQDEDEEEEE GQRFYAGGSE RSGQQIVGPP RKKSPNELVD
130 140 150 160 170 180
DLFKGAKEHG AVAVERVTKS PGETSKPRPF AGGGYRLGAA PEEESAYVAG EKRQHSSQDV
190 200 210 220 230 240
HVVLKLWKSG FSLDNGELRS YQDPSNAQFL ESIRRGEVPA ELRRLAHGGQ VNLDMEDHRD
250 260 270 280 290 300
EDFVKPKGAF KAFTGEGQKL GSTAPQVLST SSPAQQAENE AKASSSILID ESEPTTNIQI
310 320 330 340 350 360
RLADGGRLVQ KFNHSHRISD IRLFIVDARP AMAATSFILM TTFPNKELAD ESQTLKEANL
LNAVIVQRLT