Q5RB40

PR
Gene name
ARHGAP45
Protein name
Rho GTPase-activating protein 45
Names
Minor histocompatibility protein HA-1
Species
Mus musculus (Mouse)
KEGG Pathway
pon:100174429
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

296-566 (N-terminal BAR domain) SS

Target domain

728-1163 (C1-GAP-tail domains)

Relief mechanism

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5RB40

Entry ID Method Resolution Chain Position Source
AF-Q5RB40-F1 Predicted AlphaFoldDB

No variants for Q5RB40

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5RB40

No associated diseases with Q5RB40

8 regional properties for Q5RB40

Type Name Position InterPro Accession
domain EF-hand domain 316 - 351 IPR002048
domain GTP binding domain 430 - 522 IPR006073
domain Mitochondrial Rho GTPase 1/3, EF hand associated, type-1 353 - 421 IPR013566
domain EF hand associated, type-2 230 - 315 IPR013567
binding_site EF-Hand 1, calcium-binding site 208 - 220 IPR018247-1
binding_site EF-Hand 1, calcium-binding site 329 - 341 IPR018247-2
domain MIRO domain 12 - 179 IPR020860-1
domain MIRO domain 425 - 599 IPR020860-2

Functions

Description
EC Number
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
ruffle membrane The portion of the plasma membrane surrounding a ruffle.

2 GO annotations of molecular function

Name Definition
GTPase activator activity Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVVLLCLCVL LWEEAHGWGF KNGIFHNSIW LEQAAGVYHR EARAGRYKLT YAEAKAVCEF
70 80 90 100 110 120
EGGRLATYKQ LEAARKIGFH VCAAGWMAKG RVGYPIVKPG PNCGFGKTGI IDYGIRLNRS
130 140 150 160 170 180
ERWDAYCYNP HAKECGGVFT DPKRIFKSPG FPNEYDDNQV CYWHIRLKYG QRIHLSFLDF
190 200 210 220 230 240
DLEHDPGCLA DYVEIYDSYD DVHGFVGRYC GDELPEDIIS TGNVMTLKFL SDASVTAGGF
250 260 270
QIKYVTVDPA SKSSQAKNTS TTGNKKFLPG RFSHL