Q5RB37
Gene name |
ITIH3 |
Protein name |
Inter-alpha-trypsin inhibitor heavy chain H3 |
Names |
ITI heavy chain H3, ITI-HC3, Inter-alpha-inhibitor heavy chain 3 |
Species |
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) |
KEGG Pathway |
pon:100172506 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5RB37
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5RB37-F1 | Predicted | AlphaFoldDB |
No variants for Q5RB37
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5RB37 | |||||
No associated diseases with Q5RB37
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| serine-type endopeptidase inhibitor activity | Binds to and stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| hyaluronan metabolic process | The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVALSHLGSA | LQLGSLWGFP | RSPFRLLGKR | SLPEGVANGI | EVYSTKINSK | VTSRFAHNVV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TTRVVNHADT | AKEVSFDVEL | PKTAFITNFT | LTIDGVIYPG | NVKEKEVAKK | QYEKAVSQGK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TAGLVKASGR | KLEKFTVSVN | VAAGSKVTFE | LTYEELLKRH | KGKYEMYLKV | QPKQLVKHFE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IEVDIFEPQG | ISMLDAEASF | ITNDLLGSAL | TKSFSGKKGH | VSFKPSLDQQ | RPCPTCTDSL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LNGDFTITYD | VNRESPGNVQ | IVNGYFVHFF | APQGLPVVPK | NVAFVIDISG | SMAGRKLEQT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KEALLRILED | MKKEDYLNFI | LFSGDVSTWK | EHLVQATPEN | LQEARTFVKS | MEDKGMTNIN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DGLLRGISML | NKAREEHRVP | ERSTSIVIML | TDGDANVGES | RPEKIQENVR | NAIGGKFPLY |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NLGFGNNLNY | NFLENMALEN | HGFARRIYED | SDADLQLQGF | YEEVANPLLT | GVEVEYPENA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ILDLTQNTYQ | HFYDGSEIVV | AGRLVDEDMN | SFKADVKGHG | ATNDLTFTEE | VDMKEMEKAL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| QERDYIFGNY | IERLWAYLTI | EQLLEKRKNA | HGEEKENLTA | RALDLSLKYH | FVTPLTSMVV |
| 610 | 620 | 630 | 640 | 650 | 660 |
| TKPEDNEDER | AIADKPGEDA | EASYQPPQNP | YYYVDGDPHF | IIQVPEKDDA | LCFNIDEAPG |
| 670 | 680 | 690 | 700 | 710 | 720 |
| TVLRLIQDPV | TGLTVNGQII | GDKRGSPDSK | TKKTYFGKLG | IANAQMDFQV | EVTTEKVTLW |
| 730 | 740 | 750 | 760 | 770 | 780 |
| NRAVQSTFSW | LDTVTVMQDG | LSMMINRKNM | VVSFGDGVTF | VVVLHQVWKK | HPVHRDFLGF |
| 790 | 800 | 810 | 820 | 830 | 840 |
| YVVDSHRMSA | QTHGLLGQFF | QPFDFKVSDI | RPGSDPTKPD | ATLLVKNHQL | IVTRGSQKDY |
| 850 | 860 | 870 | |||
| RKDASIGTKV | VRWFVYNNGE | GLIDGVHTDY | IVPNLF |