Q5RAN9

PR
Gene name
CASQ2
Protein name
Calsequestrin-2
Names
Calsequestrin, cardiac muscle isoform
Species
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
KEGG Pathway
pon:100172607
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

330-400 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5RAN9

Entry ID Method Resolution Chain Position Source
AF-Q5RAN9-F1 Predicted AlphaFoldDB

No variants for Q5RAN9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5RAN9

No associated diseases with Q5RAN9

5 regional properties for Q5RAN9

Type Name Position InterPro Accession
conserved_site Calsequestrin, conserved site 20 - 34 IPR018233-1
conserved_site Calsequestrin, conserved site 357 - 376 IPR018233-2
domain Calsequestrin, middle TRX-fold domain 145 - 246 IPR041858
domain Calsequestrin, N-terminal TRX-fold domain 24 - 143 IPR041859
domain Calsequestrin, C-terminal TRX-fold domain 247 - 366 IPR041860

Functions

Description
EC Number
Subcellular Localization
  • Sarcoplasmic reticulum lumen
  • This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of cardiac and slow skeletal muscle cells
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
sarcoplasmic reticulum lumen The volume enclosed by the membranes of the sarcoplasmic reticulum.

1 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKRTHLFIVG VYVLSSCRAE EGLNFPTYDG KDRVVSLSEK NFKQVLKKYD LLCLYYHEPV
70 80 90 100 110 120
SSDKVAQKQF QLKEIVLELV AQVLEHKAIG FVMVDAKKEA KLAKKLGFDE EGSLYILKGD
130 140 150 160 170 180
RTIEFDGEFA ADVLVEFLLD LIEDPVEIIS SKLEVQAFER IEDYIKLIGF FKSGDSEYYK
190 200 210 220 230 240
AFEEAAEHFQ PYIKFFATFD KGVAKKLSLK MNEVDFYEPF MDEPIAIPNK PYTEEELVEF
250 260 270 280 290 300
VKEHQRPTLR RLRPEEMFET WEDDLNGIHI VAFAEKSDPD GYEFLEILKQ VARDNTDNPD
310 320 330 340 350 360
LSILWIDPDD FPLLVAYWEK TFKIDLFRPQ IGVVNVTDAD SVWMEIPDDD DLPTAEELED
370 380 390
WIEDVLSGKI NTEDDDDEDD DDDNSDEEDN DDSDDDDDDE