Q5RAF2

PR
Gene name
TPX2
Protein name
Targeting protein for Xklp2
Names
Species
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
KEGG Pathway
pon:100172669
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

124-231 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5RAF2

Entry ID Method Resolution Chain Position Source
AF-Q5RAF2-F1 Predicted AlphaFoldDB

No variants for Q5RAF2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5RAF2

No associated diseases with Q5RAF2

5 regional properties for Q5RAF2

Type Name Position InterPro Accession
domain Aurora-A binding 1 - 68 IPR015128
domain TPX2, C-terminal 542 - 588 IPR027329-1
domain TPX2, C-terminal 652 - 726 IPR027329-2
domain TPX2 central domain 365 - 450 IPR027330-1
domain TPX2 central domain 448 - 488 IPR027330-2

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm, cytoskeleton, spindle
  • Cytoplasm, cytoskeleton, spindle pole
  • During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus
  • Is released from the nucleus in apoptotic cells and is detected on apoptotic microtubules
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
spindle The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.
spindle pole Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.

1 GO annotations of molecular function

Name Definition
importin-alpha family protein binding Binding to a member of the importin-alpha family.

5 GO annotations of biological process

Name Definition
activation of protein kinase activity Any process that initiates the activity of an inactive protein kinase.
apoptotic process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
mitotic spindle assembly Mitotic bipolar spindle assembly begins with spindle microtubule nucleation from the separated spindle pole body, includes spindle elongation during prometaphase, and is complete when all kinetochores are stably attached the spindle, and the spindle assembly checkpoint is satisfied.
regulation of mitotic spindle organization Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSQVKSSYSY DAPSDFINFS SLDDEGDTQN IDSWFEEKAN LENKLLGKSG TGGLFQGKTP
70 80 90 100 110 120
LRKANLQQAI VTPLKPVDNT YYKEAEKENL VEQSIPSNAC SSLEVEAAIS RKTPAQPQRR
130 140 150 160 170 180
SLRLSAQKDL KQKEKHNVKM KAKRCATPVI IDEILPSKKM KVSNKKKPEE EGSAHRDTSE
190 200 210 220 230 240
KNASSPEKAK GRHTVPCMPP AKQKVLKSTE EQELEKSMKM QQEVVEMRKK NEEFKKLALA
250 260 270 280 290 300
GIGQPVKKSV SQVTKSIDFH FRTDERIKQH PKNQEEYKEV NFTSELRKHP SSPARVTKGC
310 320 330 340 350 360
TVVKPFNLSQ GKKRTFDETV STYVPLAQQV EDFHKRTPNR YHLRSKKDDI NLLPSKSSVT
370 380 390 400 410 420
KIGRDPQTPV LQTKYRARPV TCKSTAELEA EELEKLQQYK FKARELDPRI LEGGPILPKK
430 440 450 460 470 480
PPVKPPTEPI GFDLEIEKRI QERESKKKSE DEHFEFHSRP CPTKILEDVV GVPEKKVLPI
490 500 510 520 530 540
TVPKSPAFAL KNRIRMPTEE DEEEDEPVVI KAQPVPHYGV PFKPQIPEAR TVEICPFSFD
550 560 570 580 590 600
SRDKERQLQK EKKIKELQKG EVPKFKALPL PHFDTINLPE KKVKNVTQIE PFCLETDRGG
610 620 630 640 650 660
ALKAQTWKHQ LEEELRQQKE AACFKARPNT VISQEPFVPK KEKKSVAVQE PFQLATEKRA
670 680 690 700 710 720
KERQELEKRM AEVEAQKAQQ LEEARQQEEE QKKEELARLR RELVHKANPI RKYQGLEIKS
730
SDQPLTVPVS PKFSTRFHC