Q5RAE1

PR
Gene name
CPNE3
Protein name
Copine-3
Names
Copine III
Species
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
KEGG Pathway
pon:100174464
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

67-154 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5RAE1

Entry ID Method Resolution Chain Position Source
AF-Q5RAE1-F1 Predicted AlphaFoldDB

No variants for Q5RAE1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5RAE1

No associated diseases with Q5RAE1

5 regional properties for Q5RAE1

Type Name Position InterPro Accession
domain C2 domain 1 - 115 IPR000008-1
domain C2 domain 124 - 247 IPR000008-2
domain von Willebrand factor, type A 289 - 495 IPR002035
domain Copine, C-terminal 263 - 524 IPR010734
domain Copine, C2B domain 139 - 251 IPR037768

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
  • Cell membrane
  • Cell junction
  • Cell junction, focal adhesion
  • Associates to the membrane in a calcium-dependent manner
  • Translocates to the cell membrane and the nucleus in a calcium- or growth factor heregulin-dependent manner
  • Colocalizes with the tyrosine phosphorylated ERBB2 form at cell membrane and focal adhesions in a calcium- or growth factor heregulin-dependent manner
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cell junction A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
focal adhesion A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ).
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
calcium-dependent phospholipid binding Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium.
calcium-dependent protein binding Binding to a protein or protein complex in the presence of calcium.
metal ion binding Binding to a metal ion.

4 GO annotations of biological process

Name Definition
cellular response to calcium ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
cellular response to growth factor stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus.
ERBB2 signaling pathway The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB2 on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB2 receptors are themselves unable to bind to ligands, but act as a signal-amplifying tyrosine kinase within a heterodimeric pair.
positive regulation of cell migration Any process that activates or increases the frequency, rate or extent of cell migration.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAAQCVTKVA LNVSCANLLD KDIGSKSDPL CVLFLNTSGQ QWYEVERTER IKNCLNPQFS
70 80 90 100 110 120
KTFIIDYYFE VVQKLKFGVY DIDNKTIELS DDDFLGECEC TLGQVVSSKK LTRPLVMKNG
130 140 150 160 170 180
RPAGKGSITI SAEEIKDNRV VLFEMEARKP DNKDLFGKSD PYLEFHKQTS DGNWLMVHRT
190 200 210 220 230 240
EVVKNNLNPV WRPFKISLNS LCYGDMDKTI KVECYDYDND GSHDLIGTFQ TTMTKLKEAS
250 260 270 280 290 300
RCSPVEFECI NEKKRQKKKS YKNSGVISVK QCEITVECTF LDYIMGGCQL NFTVGVDFTG
310 320 330 340 350 360
SNDDPRSPDS LHYISPNGVN EYLTALWSVG LVIQDYDADK MFPAFGFGAQ IPPQWQVSHE
370 380 390 400 410 420
FPMNFNPSNP YCNGIQGIVE AYRSCLPQIK LYGPTNFSPI INHVARFAAA AAQQQTASQY
430 440 450 460 470 480
FVLLIITDGV ITDLDETRQA IVNASRLPMS IIIVGVGGAD FSAMEFLDGD GGGLRSPSGE
490 500 510 520 530
VAIRDIVQFV PFRQFQNAPK EALAQCVLAE IPQQVVGYFN TYKLLPPKNP ATKQQKQ