Q5RA72

PR
Gene name
GFAP
Protein name
Glial fibrillary acidic protein
Names
GFAP
Species
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
KEGG Pathway
pon:100172719
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

351-426 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5RA72

Entry ID Method Resolution Chain Position Source
AF-Q5RA72-F1 Predicted AlphaFoldDB

No variants for Q5RA72

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5RA72

No associated diseases with Q5RA72

3 regional properties for Q5RA72

Type Name Position InterPro Accession
domain Intermediate filament head, DNA-binding domain 8 - 66 IPR006821
conserved_site Intermediate filament protein, conserved site 363 - 371 IPR018039
domain Intermediate filament, rod domain 68 - 377 IPR039008

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Associated with intermediate filaments
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
intermediate filament A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name Definition
intermediate filament organization Control of the spatial distribution of intermediate filaments; includes organizing filaments into meshworks, bundles, or other structures, as by cross-linking.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MERRRITSAA RRSYISSGEM MVGGLAPGRR LGPGTRLSLA RMPPPLPTRV DFSLAGALNA
70 80 90 100 110 120
GFKETRASER AEMMELNDRF ASYIEKVRFL EQQNKALAAE LNQLRAKEPT KLADVYQAEL
130 140 150 160 170 180
RELRLRLDQL TANSARLEVE RDNLAQDLGT VRQKLQDETN LRLEAENNLA AYRQEADEAT
190 200 210 220 230 240
LARLDLERKT ESLEEEIRFL RKIHEEEVRE LQEQLARQQV HVELDMAKPD LTAALKEIRT
250 260 270 280 290 300
QYEAMASSNM HEAEEWYRSK FADLTDAAAR NAELLRQAKH EANDYRRQLQ SLTCDLESLR
310 320 330 340 350 360
GTNESLERQM REQEERHARE AASYQEALAR LEEEGQSLKD EMARHLQEYQ DLLNVKLALD
370 380 390 400 410 420
IEIATYRKLL EGEENRITIP VQTFSNLQIR ETSLDTKSVS EGHLKRNIVV KTVEMRDGEV
430
IKESKQEHKD VM