Q5R9W5

PR
Gene name
WWOX
Protein name
WW domain-containing oxidoreductase
Names
Species
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
KEGG Pathway
pon:100172779
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

67-144 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5R9W5

Entry ID Method Resolution Chain Position Source
AF-Q5R9W5-F1 Predicted AlphaFoldDB

No variants for Q5R9W5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5R9W5

No associated diseases with Q5R9W5

3 regional properties for Q5R9W5

Type Name Position InterPro Accession
domain WW domain 16 - 49 IPR001202-1
domain WW domain 57 - 90 IPR001202-2
domain WWOX, classical (c)-like SDR domain 124 - 407 IPR042732

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Mitochondrion
  • Golgi apparatus
  • Lysosome
  • Partially localizes to the mitochondria (By similarity)
  • Translocates to the nucleus upon genotoxic stress or TNF stimulation (By similarity)
  • Translocates to the nucleus in response to TGFB1
  • Isoform 5 and isoform 6 may localize in the nucleus (By similarity)
  • Localized to the lysosome probably upon binding to VOPP1 (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name Definition
oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

3 GO annotations of biological process

Name Definition
apoptotic process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
negative regulation of Wnt signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway.
Wnt signaling pathway The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAALRYAGLD DTDSEDELPP GWEERTTKDG WVYYANHTEE KTQWEHPKTG KRKRVAGDLP
70 80 90 100 110 120
YGWEQGTDEN GQVFFVDHIN KRTTYLDPRL AFTVDDNPTK PTTRQRYDGS TTALEILQGR
130 140 150 160 170 180
DFTGKVVVVT GANSGIGFET AKSFALHGAH VILACRNMAR ASEAVSRILE EWHKAKVEAV
190 200 210 220 230 240
TLDLALLRSV QHFAEAFKAK NVPLHVLVCN AATFALPWSL TKDGLETTFQ VNHLGHFYLV
250 260 270 280 290 300
QLLQDVLCRS APARVIVVSS ESHRFTDIND SLGKLDFSRL SPTKNDYWAM LAYNRSKLCN
310 320 330 340 350 360
VLFSNELHRR LSPRGVTSNA VHPGNMMYSN IHRSWWVYTL LFTLARPFTK SMQQGAATTV
370 380 390 400 410
YCAAAPELEG LGGMYFNNCC RCMPSPEAQS EETARTLWAL SERLIQERLG SQSG