Q5R9C2

PR
Gene name
SLC6A15 (B0AT2)
Protein name
Sodium-dependent neutral amino acid transporter B(0)AT2
Names
Sodium- and chloride-dependent neurotransmitter transporter NTT73, Solute carrier family 6 member 15, Transporter v7-3
Species
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
KEGG Pathway
pon:100174517
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

12-85 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5R9C2

Entry ID Method Resolution Chain Position Source
AF-Q5R9C2-F1 Predicted AlphaFoldDB

No variants for Q5R9C2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5R9C2

No associated diseases with Q5R9C2

2 regional properties for Q5R9C2

Type Name Position InterPro Accession
domain Bicarbonate transporter-like, transmembrane domain 396 - 912 IPR011531
domain Band 3 cytoplasmic domain 95 - 344 IPR013769

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

3 GO annotations of molecular function

Name Definition
branched-chain amino acid:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: branched-chain amino acid(out) + cation(out) = branched-chain amino acid(in) + cation(in).
neutral amino acid:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral amino acid(out) + Na+(out) = neutral amino acid(in) + Na+(in).
proline:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + Na+(out) = proline(in) + Na+(in).

4 GO annotations of biological process

Name Definition
leucine transport The directed movement of leucine, 2-amino-4-methylpentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
neurotransmitter transport The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell.
neutral amino acid transport The directed movement of neutral amino acids, amino acids with no net charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
proline transport The directed movement of proline, pyrrolidine-2-carboxylic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPKNSKVVKR ELDDDVTESV KDLLSNEDSA DDAFKTSELI VDGQEEKDTD VEEGSEVEDE
70 80 90 100 110 120
RPAWSSKLQY ILAQVGFSVG LGNVWRFPYL CQKNGGGAYL LPYLILLMVI GIPLFFLELS
130 140 150 160 170 180
VGQRIRRGSI GVWNYISPKL GGIGFASCVV CYFVALYYNV IIGWSLFYFS QSFQQPLPWD
190 200 210 220 230 240
QCPLVKNASH TFVEPECEQS SATTYYWYRE ALNISSSISE SGGLNWKMTI CLLAAWVMVC
250 260 270 280 290 300
LAMIKGIQSS GKIIYFSSLF PYVVLICFLI RALLLNGSID GIRHMFTPKL EIMLEPKVWR
310 320 330 340 350 360
EAATQVFFAL GLGFGGVIAF SSYNKRDNNC HFDAVLVSFI NFFTSVLATL VVFAVLGFKA
370 380 390 400 410 420
NVINEKCITQ NSQTIMKFLK MGNISQDIIP HHINLSAVTA EDYHLVYDII QKVKEEEFPA
430 440 450 460 470 480
LHLNSCKIEE ELNKAVQGTG LAFIAFTEAM THFPASPFWS VMFFLMLVNL GLGSMFGTIE
490 500 510 520 530 540
GIVTPIVDTF KVRKEILTVI CCLLAFCIGL IFVQRSGNYF VTMFDDYSAT LPLLIVVILE
550 560 570 580 590 600
NIAVCFVYGI DKFMEDLKDM LGFAPSRYYY YMWKYVSPLM LLSLLIASVV NMGLSPPGYN
610 620 630 640 650 660
AWIEDKASEE FLSYPTWGLV VCVSLVVFAV LPVPVVFIVR RFNLIDDSSG NLASVTYKRG
670 680 690 700 710 720
RVLNEPVNLE GDDTSLIHGK ISSEMPSPNF GKNIYRKQSG SPTLDTAPNG RYGIGYLMAD
IMPDMPESDL