Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5R9B2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5R9B2-F1 | Predicted | AlphaFoldDB |
No variants for Q5R9B2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5R9B2 | |||||
No associated diseases with Q5R9B2
1 regional properties for Q5R9B2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Ras guanine-nucleotide exchange factors catalytic domain | 214 - 455 | IPR001895 |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| guanyl-nucleotide exchange factor activity | Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| small GTPase mediated signal transduction | The series of molecular signals in which a small monomeric GTPase relays a signal. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEGPEGLGRK | QACLAMLLHF | LDTYQGLLQE | EEGAGHIIKD | LYLLIMKDES | LYQGLREDTL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RLHQLVETVE | LKIPEENQPP | SKQVKPLFRH | FRRIDSCLQT | RVAFRGSDEI | FCRVYMPDHS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YVTIRSRLSA | SVQDILGSVT | EKLQYSEEPA | GREDSLILVA | VSSSGEKVLL | QPTEDCVFTA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LGINSHLFAC | TRDSYEALVP | LPEEIQVSPG | DTEIHRVEPE | DVANHLTAFH | WELFRCVHEL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EFVDYVFHGE | RGRRETANLE | LLLQRCSEVT | HWVATEVLLC | EAPGKRAQLL | KKFIKIAALC |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KQNQDLLSFY | AVVMGLDNAA | VSRLRLTWEK | LPGKFKNLFR | KFENLTDPCR | NHKSYREVIS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KMKPPVIPFV | PLILKDLTFL | HEGSKTLVDG | LVNIEKLHSV | AEKVRTIRKY | RSRPLYLDME |
| 430 | 440 | 450 | |||
| ASPHHLQTKA | YVRQFQVIDN | QNLLFELSYK | LEANSQ |