Q5R981

PR
Gene name
CMTR1 (FTSJD2)
Protein name
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
Names
Cap methyltransferase 1, Cap1 2'O-ribose methyltransferase 1, MTr1, FtsJ methyltransferase domain-containing protein 2
Species
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
KEGG Pathway
pon:100172922
EC number
2.1.1.57: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-153 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5R981

Entry ID Method Resolution Chain Position Source
AF-Q5R981-F1 Predicted AlphaFoldDB

2 variants for Q5R981

Variant ID(s) Position Change Description Diseaes Association Provenance
rs177558437 43 A>T No Ensembl
rs177558493 556 S>L No Ensembl

No associated diseases with Q5R981

4 regional properties for Q5R981

Type Name Position InterPro Accession
domain G-patch domain 85 - 133 IPR000467
domain WW domain 753 - 786 IPR001202
domain Ribosomal RNA methyltransferase, FtsJ domain 233 - 448 IPR002877
domain RrmJ-type ribose 2-O-methyltransferase domain 231 - 450 IPR025816

Functions

Description
EC Number 2.1.1.57 Methyltransferases
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
mRNA (nucleoside-2'-O-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + m7G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA. R may be guanosine or adenosine.
nucleic acid binding Binding to a nucleic acid.

3 GO annotations of biological process

Name Definition
7-methylguanosine mRNA capping Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript.
cap1 mRNA methylation Methylation of the ribose of the first nucleotide of a 5'-capped mRNA.
mRNA methylation The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKRRTDPECT APIKKQKKRV AELALSLSST SDDEPPSSVS HGAKASTTSL SGSDSETEGK
70 80 90 100 110 120
QHSSDSFDDA FKADSLVEGT SSRYSMYNSV SQKLMAKMGF REGEGLGKYS QGRKDIVEAS
130 140 150 160 170 180
SQKGRRGLGL TLRGFDQELN VDWRDEPEPS ACEQVSWFPE CTTEIPDTQE MSDWMVVGKR
190 200 210 220 230 240
KMIIEDETEF CGEELLHSVL QCKSVFDVLD GEEMRRARTR ANPYEMIRGV FFLNRAAMKM
250 260 270 280 290 300
ANMDFVFDRM FTNPRDSYGK PLVKDREAEL LYFADVCAGP GGFSEYVLWR KKWHAKGFGM
310 320 330 340 350 360
TLKGPNDFKL EDFYSASSEL FEPYYGEGGI DGDGDITRPE NISAFRNFVL DNTDRKGVHF
370 380 390 400 410 420
LMADGGFSVE GQENLQEILS KQLLLCQFLM ALSIVRTGGH FICKTFDLFT PFSVGLVYLL
430 440 450 460 470 480
YCCFERVCLF KPITSRPANS ERYVVCKGLK VGIDDVRDYL FAVNIKLNQL RNTDSDVNLV
490 500 510 520 530 540
VPLEVIKGDH EFTDYMIRSN ESHCSLQIKA LAKIHAFVQD TTLSEPRQAE IRKECLRLWG
550 560 570 580 590 600
IPDQARVAPS SSDPKSKFFE LIQGTEIDIF SYKPTLLTSK TLEKIRPVFD YRCMVSGSEQ
610 620 630 640 650 660
KFLIGLGKSQ IYTWDGRQSD RWIKLDLKTE LPRDTLLSVE IVHELKGEGK AQRKISAIHI
670 680 690 700 710 720
LDVLVLNGTD VREQHFNQRI QLAEKFVKAV SKPSRPDMNP IRVKEVYRLE EMEKIFVRLE
730 740 750 760 770 780
MKIIKGSSGT PKLSYTGRDD RHFVPMGLYI VRTVNEPWTM GFSKSFKKKF FYNKKTKDST
790 800 810 820 830
FDLPADSIAP FHICYYGRLF WEWGDGIRVH DSQKPQDQDK LSKEDVLSFI QMHRA