Q5R949
Gene name |
CHRM1 |
Protein name |
Muscarinic acetylcholine receptor M1 |
Names |
|
Species |
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) |
KEGG Pathway |
pon:100172935 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5R949
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5R949-F1 | Predicted | AlphaFoldDB |
No variants for Q5R949
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5R949 | |||||
No associated diseases with Q5R949
No regional properties for Q5R949
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q5R949 | |||
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| postsynaptic membrane | A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| G protein-coupled acetylcholine receptor activity | Combining with acetylcholine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cognition | The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory. |
| regulation of locomotion | Any process that modulates the frequency, rate or extent of locomotion of a cell or organism. |
| saliva secretion | The regulated release of saliva from the salivary glands. In man, the saliva is a turbid and slightly viscous fluid, generally of an alkaline reaction, and is secreted by the parotid, submaxillary, and sublingual glands. In the mouth the saliva is mixed with the secretion from the buccal glands. In man and many animals, saliva is an important digestive fluid on account of the presence of the peculiar enzyme, ptyalin. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNTSAPPAVS | PNITVLAPGK | GPWQVAFIGI | TTGLLSLATV | TGNLLVLISF | KVNTELKTVN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NYFLLSLACA | DLIIGTFSMN | LYTTYLLMGH | WALGTLACDL | WLALDYVASN | ASVMNLLLIS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FDRYFSVTRP | LSYRAKRTPR | RAALMIGLAW | LVSFVLWAPA | ILFWQYLVGE | RTVLAGQCYI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QFLSQPIITF | GTAMAAFYLP | VTVMCTLYWR | IYRETESRAR | ELAALQGSET | PGKGGGSSSS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SERSQPGAEG | SPGTPPGRCC | RCCRAPRLLQ | AYSWKEEEEE | DEGSMESLTS | SEGEEPGSEV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VIKMPMVDPE | AQAPTKQPPR | SSPNTVKRPT | KKGRDRAGKG | QKPRGKEQLA | KRKTFSLVKE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KKAARTLSAI | LLAFILTWTP | YNIMVLVSTF | CKDCVPETLW | ELGYWLCYVN | STINPMCYAL |
| 430 | 440 | 450 | |||
| CNKAFRDTFR | LLLLCRWDKR | RWRKIPKRPG | SVHRTPSRQC |