Q5R8P5

PR
Gene name
SH3GLB1
Protein name
Endophilin-B1
Names
SH3 domain-containing GRB2-like protein B1
Species
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
KEGG Pathway
pon:100173032
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

235-322 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5R8P5

Entry ID Method Resolution Chain Position Source
AF-Q5R8P5-F1 Predicted AlphaFoldDB

No variants for Q5R8P5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5R8P5

No associated diseases with Q5R8P5

4 regional properties for Q5R8P5

Type Name Position InterPro Accession
domain SH3 domain 305 - 365 IPR001452
domain BAR domain 10 - 261 IPR004148
domain Endophilin-B1, SH3 domain 305 - 365 IPR028503
domain Endophilin-B1, BAR domain 24 - 252 IPR035695

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Golgi apparatus membrane ; Peripheral membrane protein
  • Mitochondrion outer membrane ; Peripheral membrane protein
  • Cytoplasmic vesicle, autophagosome membrane
  • Midbody
  • Association with the Golgi apparatus depends on the cell type
  • Following starvation colocalizes with ATG5 and LC3 autophagy-related protein(s)on autophagosomal membranes
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
autophagosome membrane The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered.
cytoplasmic vesicle A vesicle found in the cytoplasm of a cell.
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
midbody A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.

1 GO annotations of molecular function

Name Definition
lipid binding Binding to a lipid.

1 GO annotations of biological process

Name Definition
apoptotic process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNIMDFNVKK LAADAGTFLS RAVQFTEEKL GQAEKTELDA HLENLLSKAE CTKIWTEKIM
70 80 90 100 110 120
KQTEVLLQPN PNARIEEFVY EKLDRKAPSR INNPELLGQY MIDAGTEFGP GTAYGNALIK
130 140 150 160 170 180
CGETQKRIGT ADRELIQTSA LNFLTPLRNF IEGDYKTIAK ERKLLQNKRL DLDAAKTRLK
190 200 210 220 230 240
KAKAAETRNS SEQELRITQS EFDRQAEITR LLLEGISSTH AHHLRCLNDF VEAQMTYYAQ
250 260 270 280 290 300
CYQYMLDLQK QLGSFPSNYL SNNNQTSVTP VPSVLPNAIG SSAMASTSGL VITSPSNLSD
310 320 330 340 350 360
LKECSGSRKA RVLYDYDAAN STELSLLADE VITVFSVVGM DSDWLMGERG NQKGKVPITY
LELLN