Q5R8G5
Gene name |
MFSD1 |
Protein name |
Major facilitator superfamily domain-containing protein 1 |
Names |
|
Species |
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) |
KEGG Pathway |
pon:100174559 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5R8G5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5R8G5-F1 | Predicted | AlphaFoldDB |
No variants for Q5R8G5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5R8G5 | |||||
No associated diseases with Q5R8G5
1 regional properties for Q5R8G5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Major facilitator superfamily domain | 42 - 445 | IPR020846 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| lysosomal membrane | The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. |
| lysosome | A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
| transmembrane transporter activity | Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| protein localization to lysosome | A process in which a protein is transported to, or maintained in, a location within a lysosome. |
| protein stabilization | Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEEEDEEARA | LLAGGPDEAD | RGAPAAPGAL | PALCDPSRLV | HRLLVLLLMC | FLGFGSYFCY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DNPAALQTQV | KRDMQVNTTK | FMLLYAWYSW | SNVVLCFFGG | FLIDRVFGIR | WGTIIFSCFV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| CIGQVVFALG | GIFNAFWLME | FGRFVFGIGG | ESLAVAQNTY | AVSWFKGKEL | NLVFGLQLSM |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ARIGSTVNMN | LMGWLYSKIE | ALLGSAGHTT | LGITLMIGGV | TCILSLICAL | ALAYLDQRAE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RILHKEQGKT | GEVIKLTDVK | DFSLPLWLIF | IICVCYYVAV | FPFIGLGKVF | FTEKFGFSSQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AASAINSVVY | VISAPMSPVF | GLLVDKTGKN | IIWVLCAVAA | TLVSHMMLAF | TMWNPWIAMC |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LLGLSYSLLA | CALWPMVAFV | VPEHQLGTAH | GFMQSIQNLG | LAIISIIAGM | ILDSRGYLFL |
| 430 | 440 | 450 | 460 | ||
| EVFFIACVSL | SLLSVVLLYL | VNRAQGGNLN | YSARQREEIK | FSHTE |