Q5R7X0
Gene name |
FTO |
Protein name |
Alpha-ketoglutarate-dependent dioxygenase FTO |
Names |
Fat mass and obesity-associated protein, U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO, U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO, mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO, m6A(m)-demethylase FTO, mRNA N(6)-methyladenosine demethylase FTO, tRNA N1-methyl adenine demethylase FTO |
Species |
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) |
KEGG Pathway |
pon:100173222 |
EC number |
1.14.11.53: With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5R7X0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5R7X0-F1 | Predicted | AlphaFoldDB |
No variants for Q5R7X0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5R7X0 | |||||
No associated diseases with Q5R7X0
Functions
| Description | ||
|---|---|---|
| EC Number | 1.14.11.53 | With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nuclear speck | A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-N1-methyladenine dioxygenase activity | Catalysis of the oxidative demethylation of N1-methyladenine and N3-methylcytosine in DNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N1-methyladenine and N3-methylcytosine as formaldehyde. |
| ferrous iron binding | Binding to a ferrous iron ion, Fe(II). |
| mRNA N6-methyladenosine dioxygenase activity | Catalysis of the oxidative demethylation of N6-methyladenosine RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N6-methyladenosine as formaldehyde. |
| oxidative DNA demethylase activity | Catalysis of the reaction: a methylated nucleobase within DNA + 2-oxoglutarate + O(2) = a nucleobase within DNA + formaldehyde + succinate + CO(2). |
| oxidative RNA demethylase activity | Catalysis of the removal of a methyl group from one or more nucleosides within a RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms. |
| tRNA demethylase activity | Catalysis of the removal of a methyl group from one or more positions within a tRNA molecule. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA dealkylation involved in DNA repair | The repair of alkylation damage, e.g. the removal of the alkyl group at the O6-position of guanine by O6-alkylguanine-DNA alkyltransferase (AGT). |
| mRNA destabilization | Any process that decreases the stability of an mRNA molecule, making it more vulnerable to degradative processes. Messenger RNA is the intermediate molecule between DNA and protein. It includes UTR and coding sequences. It does not contain introns. |
| oxidative single-stranded DNA demethylation | Removal of the methyl group from one or more nucleotides within a single-stranded DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms. |
| oxidative single-stranded RNA demethylation | Removal of the methyl group from one or more nucleotides within a single-stranded RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms. |
| regulation of multicellular organism growth | Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size. |
| RNA repair | Any process that results in the repair of damaged RNA. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKRTPTAEER | EREAKKLRLL | EELEDTWLPY | LTPKDDEFYQ | QWQLKYPKLI | LREASSVSEE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LHKEVQEAFL | TMHKHGCLFR | DLVRIQGKDL | LTPVSRILIG | NPGCTYKYLN | TRLFTVPWPV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KGSNIKHTEA | EIAAACETFL | KLNDYLQIET | IQALEELAAK | EKANEDTVPL | CMSADFPRVG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MGSSYNGQDE | VDIKSRAAYN | VTLLNFMDPQ | KMPYLKEEPY | FGMGKMAVSW | HHDENLVDRS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AVAVYSYSCE | GPEEESEDDS | HLEGRDPDIW | HVGFKISWDI | ETPGLAIPLH | QGDCYFMLDD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LNATHQHCVL | AGSQPRFSST | HRVAECSTGT | LDYILQRCQL | APQNVRDDVE | NDDVSLKSFE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PAVLKQGEEI | HNEVEFEWLR | QFWFQGNRYR | KCTDWWCQPM | AQLEALWKKM | EAVTNAVLHE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VKREGLPVEQ | RNEILTAILA | SLTARQNLRR | EWHARCQSRI | ARTLPADQKP | ECRPYWEKDD |
| 490 | 500 | ||||
| VSMPLPFDLT | DIVSELRGQL | LEAKP |