Q5R7T9
Gene name |
MTF2 |
Protein name |
Metal-response element-binding transcription factor 2 |
Names |
Metal regulatory transcription factor 2 |
Species |
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) |
KEGG Pathway |
pon:100173244 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5R7T9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5R7T9-F1 | Predicted | AlphaFoldDB |
1 variants for Q5R7T9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs171050884 | 281 | H>N | No | Ensembl |
No associated diseases with Q5R7T9
9 regional properties for Q5R7T9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Zinc finger, PHD-type | 104 - 155 | IPR001965-1 |
| domain | Zinc finger, PHD-type | 203 - 253 | IPR001965-2 |
| domain | Tudor domain | 44 - 101 | IPR002999 |
| conserved_site | Zinc finger, PHD-type, conserved site | 105 - 154 | IPR019786 |
| domain | Zinc finger, PHD-finger | 102 - 157 | IPR019787 |
| domain | Polycomb-like MTF2 factor 2, C-terminal domain | 545 - 591 | IPR025894 |
| domain | Lysine-specific demethylase 4-like, Tudor domain | 49 - 84 | IPR040477 |
| domain | MTF2, PHD domain 1 | 104 - 156 | IPR042014 |
| domain | MTF2, PHD domain 2 | 203 - 254 | IPR042015 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| metal ion binding | Binding to a metal ion. |
| methylated histone binding | Binding to a histone in which a residue has been modified by methylation. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| chromatin organization | The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA. |
| negative regulation of histone H3-K27 methylation | Any process that decreases the rate, frequency, or extent of histone H3-K27 methylation. Histone H3-K27 methylation is the modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| positive regulation of histone H3-K27 methylation | Any process that increases the rate, frequency, or extent of histone H3-K27 methylation. Histone H3-K27 methylation is the modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| segment specification | The process in which segments assume individual identities; exemplified in insects by the actions of the products of the homeotic genes. |
| stem cell differentiation | The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. |
| stem cell population maintenance | The process by which an organism or tissue maintains a population of stem cells of a single type. This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRDSTGAGNS | LVHKRSPLRR | NQKTPTSLTK | LSLQDGHKAK | KPACKFEEGQ | DVLARWSDGL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FYLGTIKKIN | ILKQSCFIIF | EDSSKSWVLW | KDIQTGATGS | GEMVCTICQE | EYSEAPNEMV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ICDKCGQGYH | QLCHTPHIDS | SVIDSDEKWL | CRQCVFATTT | KRGGALKKGP | NAKALQVMKQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TLPYSVADLE | WDAGHKTNVQ | QCYCYCGGPG | DWYLKMLQCC | KCKQWFHEAC | VQCLQKPMLF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GDRFYTFICS | VCSSGPEYLK | RLPLQWVDIA | HLCLYNLSVI | HKKKYFDSEL | ELMTYINENW |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DRLHPGELAD | TPKSERYEHV | LEALNDYKTM | FMSGKEIKKK | KHLFGLRIRV | PPVPPNVAFK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AEKEPEGTSH | EFKIKGRKAS | KPISDSREVS | NGIEKKGKKK | SVGRPPGPYT | RKMIQKTAEP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LLDKESISEN | PTLDLPCSIG | RTEGTAHSSN | TSDVDFTGAS | SAKETTSSSI | SRHYGLSDSR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KRTRTGRSWP | AAIPHLRRRR | GRLPRRALQT | QNSEIVKDDE | GKEDYQFDEL | NTEILNNLAD |
| 550 | 560 | 570 | 580 | 590 | |
| QELQLNHLKN | SITSYFGAAG | RIACGEKYRV | LARRVTLDGK | VQYLVEWEGA | TAS |