Q5R7Q4
PR
Gene name |
RPA1 |
Protein name |
Replication protein A 70 kDa DNA-binding subunit |
Names |
RP-A p70, Replication factor A protein 1, RF-A protein 1 |
Species |
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) |
KEGG Pathway |
pon:100173266 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5R7Q4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5R7Q4-F1 | Predicted | AlphaFoldDB |
No variants for Q5R7Q4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5R7Q4 | |||||
No associated diseases with Q5R7Q4
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| DNA replication factor A complex | A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| PML body | A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection. |
| site of DNA damage | A region of a chromosome at which DNA damage has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| damaged DNA binding | Binding to damaged DNA. |
| metal ion binding | Binding to a metal ion. |
| single-stranded DNA binding | Binding to single-stranded DNA. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| base-excision repair | In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. |
| cellular response to DNA damage stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. |
| DNA replication | The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. |
| double-strand break repair via homologous recombination | The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule. |
| mismatch repair | A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. |
| nucleotide-excision repair | A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). |
| protein localization to chromosome | Any process in which a protein is transported to, or maintained at, a specific location on a chromosome. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVGQLSEGAI | AAIMQKGDTN | IKPILQVINI | RPITTGNSPP | RYRLLMSDGL | NTLSSFMSAT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QLNPLVEQEQ | LSSNCVCQIN | RFIVNTLKDG | RRVVILMELE | VLKSAEVVGV | KIGNPVPYNE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GLGQPQVAPP | APAASPAASS | RPQPQNGTSG | AGSTVSKAYG | ASKTFGKAAG | PSLSHNSGGT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QSKVVPIASL | TPYQSKWTIC | ARVTNKSQIR | TWSNSRGEEK | LFSLELVDES | GEIRATAFNE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QVDKFFPLIE | VNKVYYFSKG | TLKIANKQFT | AVKNDYEMTF | NNETSVMPCE | DDHHLPTVQF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DFTGIDDLEN | KSKDSLVDII | GICKSYEDAT | KITVRSNNRE | VAKRNIYLMD | TSGKVVTATL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| WGEDADKFDG | SRQPVLAIKG | ARVSDFGGRS | LSVLSSSTII | ANPDIPEAYK | LRGWFDAEGQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ALDGVSISDL | KSGGVGGGNT | NWKTLYEVKS | ENLGQGDKPD | YFSSVATVVY | LRKENCMYQA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| CPTQDCNKKV | IDQQNGLYRC | EKCDTEFPNF | KYRMILSVNI | ADFQENQWVT | CFQESAEAIL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GQNAAYLGEL | KDKNEQAFEE | VFQNANFRSF | IFRVRVKVET | YNDESRIKAT | VMDVKPVDYR |
| 610 | |||||
| EYGRRLVMSI | RRSALM |