Q5R7K6

PR
Gene name
EMC1
Protein name
ER membrane protein complex subunit 1
Names
Species
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
KEGG Pathway
pon:100173298
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

317-388 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5R7K6

Entry ID Method Resolution Chain Position Source
AF-Q5R7K6-F1 Predicted AlphaFoldDB

No variants for Q5R7K6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5R7K6

No associated diseases with Q5R7K6

2 regional properties for Q5R7K6

Type Name Position InterPro Accession
repeat Pyrrolo-quinoline quinone repeat 47 - 208 IPR002372
domain ER membrane protein complex subunit 1, C-terminal 790 - 995 IPR011678

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
EMC complex A transmembrane protein complex located in the endoplasmic reticulum (ER) involved in the insertion of newly synthesized proteins in the membrane of the ER. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6.
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of endoplasmic reticulum membrane The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

2 GO annotations of biological process

Name Definition
protein insertion into ER membrane by stop-transfer membrane-anchor sequence A process of protein insertion into the endoplasmic reticulum (ER) membrane in which stop-transfer membrane-anchor sequences become an ER membrane spanning helix.
tail-anchored membrane protein insertion into ER membrane A process of protein insertion into the endoplasmic reticulum (ER) membrane in which a tail-anchored (TA) transmembrane protein is incorporated into an endoplasmic reticulum (ER) membrane. TA transmembrane protein, also named type II transmembrane proteins, contain a single C- terminal transmembrane region.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAAEWASRFW LWAALLIPVA AVYEDQVGKF DWRQQYVGKL KFASLEFSPG SKKLVVATEK
70 80 90 100 110 120
NVIAALNSRT GEILWRHVDK GTAEGAVDAM LLHGQDVITV SNGGRIMRSW ETNIGGLNWE
130 140 150 160 170 180
ITLDTGSFQA LGLVGLQESV RYIAVLKKTT LALHHLSSGH LKWVEHLPES DSIHYQMVYS
190 200 210 220 230 240
YGSGVVWALG VVPFSHVNIV KFNVEDGEIV QQVRVSTPWL QHLSGACGVV DEAVLVCPDP
250 260 270 280 290 300
SSRSLQTLAL ETEWELRQIP LQSLDLEFGS GFQPRVLPTQ PNPVDASRAQ FFLHLSPSHY
310 320 330 340 350 360
ALLQYHYGIL SLLKNFPQTA LVSFATTGEK TVAAVMACRN EVQKTSNSED GSMGSFSEKS
370 380 390 400 410 420
SSKDSLACFN QTYTINLYLV ETGRRLLDTT TTFSLEQSGT RPERLYIQVF LKKDDSVGYR
430 440 450 460 470 480
ALVQTEDHLL LFLQQLAGKV VLWSREESLA EVVCLEMVDL PLTGAQAELE GEFGKKAAIQ
490 500 510 520 530 540
DGLLGMFLKR LSSQLILLQA WTSHLWKMFY DARKPRSQIK NEINIDTLAR DEFNLQKMMV
550 560 570 580 590 600
MVTASGKLFG IESSSGTILW KQYLPSVKPD SSFKLMVQRT TAHFPHPPQC TLLVKDKESG
610 620 630 640 650 660
MSSLYVFNPI FGKWSQVAPP VLKRPILQSL LLPVMDQDYA KVLLLIDDEY KVTAFPATRN
670 680 690 700 710 720
VLRQLHELAP SIFFYLVDAE QGRLCGYRLR KDLTTELSWE LTIPPEVRRI VKVKGKRSSE
730 740 750 760 770 780
HVHSQGRVMG DRSVLYKSLN PNLLAVVTES TDAHHERTFI GIFLIDGVTG RIIHSSAQKK
790 800 810 820 830 840
AKGPVHIVHS ENWVVYQYWN TKARRNEFTV LELYEGTEQY NATAFSSLDR PQLPQVLQQS
850 860 870 880 890 900
YIFPSSISAM EATITERGIT SRHLLIGLPS GAILSLPKAL LDPRRPEIPT EQSREENLIP
910 920 930 940 950 960
YSPDVQIHAE RFINYNQTVS RMRGIYTAPS GLESTCLVVA YGLDIYQTRV YPSKQFDVLK
970 980 990
DDYDYVLISS VLFGLVFATM ITKRLAQVKL LNRAWR