Q5R7H4
Gene name |
LBR |
Protein name |
Delta(14)-sterol reductase LBR |
Names |
Delta-14-SR, 3-beta-hydroxysterol Delta (14)-reductase, C-14 sterol reductase, C14SR, Integral nuclear envelope inner membrane protein, Lamin-B receptor, Sterol C14-reductase |
Species |
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) |
KEGG Pathway |
pon:100174610 |
EC number |
1.3.1.70: With NAD(+) or NADP(+) as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5R7H4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5R7H4-F1 | Predicted | AlphaFoldDB |
No variants for Q5R7H4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5R7H4 | |||||
No associated diseases with Q5R7H4
4 regional properties for Q5R7H4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Tudor domain | 4 - 62 | IPR002999 |
| conserved_site | Sterol reductase, conserved site | 362 - 377 | IPR018083-1 |
| conserved_site | Sterol reductase, conserved site | 579 - 602 | IPR018083-2 |
| domain | Lamin-B receptor of TUDOR domain | 1 - 56 | IPR019023 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.3.1.70 | With NAD(+) or NADP(+) as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| nuclear inner membrane | The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| delta14-sterol reductase activity | Catalysis of the reaction: NADP+ + 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol = NADPH + H+ + 4,4-dimethyl-5-alpha-cholesta-8,14,24-trien-3-beta-ol. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| NADPH binding | Binding to the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| cholesterol biosynthetic process | The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. |
| neutrophil differentiation | The process in which a myeloid precursor cell acquires the specialized features of a neutrophil. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPSRKFADGE | VVRGRWPGSS | LYYEVEILSH | DSASQLYTVK | YKDGTELELK | ENDIKPLTSF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RQRKGGSTSS | SPSRRRGSRS | RSRSRSPGRP | PKSARRSASA | SHQADIKEAR | REVEVKLTPL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ILKPFGNSIS | RYNGEPEHIE | RNDVPHKNTQ | EKFNLSQESS | YIATQCSLRP | KREEVKLKEI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DSKEEKFVAK | ELAVRTFEVT | PIRAKDLEFG | GVPGVFLIMF | GLPVFLFLLL | LMCKQKDPSL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LNFPPPLPAL | YELWETRVFG | VYLLWFLIQV | VFYLLPIGKV | VEGTPLIDGR | RLKYRLNGFY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AFILTSAVIG | TSLFQGVEFH | YVYSHFLQFA | LAATVFCVVL | SVYLYMRSLK | APRNDLSPAS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SGNAVYDFFI | GRELNPRIGT | FDLKYFCELR | PGLIGWVVIN | LVMLLAEMKI | QDRAVPSLAM |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ILVNSFQLLY | VVDALWNEEA | LLTTMDIIHD | GFGFMLAFGD | LVWVPFIYSF | QAFYLVSHPN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EVSWPMASLI | IVLKFCGYVI | FRGANSQKNA | FRKNPSDPKL | AHLKTIHTST | GKNLLVSGWW |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GFARHPNYLG | DLIMALAWSL | ACGFNHILPY | FYIIYFTMLL | VHREARDEYH | CKKKYGVAWE |
| 610 | |||||
| KYCQRVPYRI | FPYIY |